2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine

Base Information

• Chemical Name: 2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine
• CAS No.: 1058062-64-8
• Molecular Formula: C13H17BF3NO2
• Molecular Weight: 287.09
• Hs Code.: 2934999090
• Mol file: 1058062-64-8.mol

Synonyms:2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine;2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoroMethyl)aniline;2-Amino-5-(trifluoromethyl)phenylboronic acid, pinacol ester

Chemical Property of 2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine

Chemical Property:

• PSA: 44.48000
• LogP: 3.16800
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine

There total 8 articles about 2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bis(pinacol)diborane (73183-34-3) + 4-amino-3-bromobenzotrifluoride (57946-63-1) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzenamine (1058062-64-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; for 10h; Reflux;

Reference yield: 71.0%

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) + 4-amino-3-bromobenzotrifluoride (57946-63-1) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzenamine (1058062-64-8)

Guidance literature:

With dichlorobis(chlorodi-tert-butylphosphine) palladium(II); triethylamine; In toluene; for 2h; Inert atmosphere; Reflux;

DOI:10.2478/s11532-010-0076-1

Reference yield: 68.0%

2-iodo-4-(trifluoromethyl)aniline (163444-17-5) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzenamine (1058062-64-8)

Guidance literature:

With N(CH₂CH₃)3; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; (Ar); addn. of triethylamine, palladium compd. and borane deriv. to dioxane soln. of aniline deriv., heating at 100°C for 5 h; cooling to room temp., filtration through celite with eluting by ethyl acetate, evapn., chromy. (silica gel, hexane/ethyl acetate (9/1 to 2/8)),NMR and MS;

DOI:10.1039/c2ob06695e

upstream raw materials:

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

2-bromo-4-trifluoromethoxyaniline

4-amino-3-bromobenzotrifluoride

2-iodo-4-(trifluoromethyl)aniline

Downstream raw materials:

1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)phenyl)urea

C₁₆H₈BF₁₁N₂O

C₁₄H₁₄F₃N₃

C₁₄H₁₆F₃N

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