Technology Process of 3-Amino-5-(trifluoromethyl)pyridine-2-carboxylic acid
There total 7 articles about 3-Amino-5-(trifluoromethyl)pyridine-2-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester;
With
sodium hydroxide;
In
methanol; water;
at 20 ℃;
for 0.5h;
With
hydrogenchloride;
In
methanol; water;
pH=1;
DOI:10.1021/acs.jmedchem.1c00343
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux
2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere
4.1: hydrogenchloride; water / 24 h / Reflux
5.1: sulfuric acid / 48 h / Reflux
5.2: 20 °C
6.1: sodium hydroxide; methanol / 0.02 h / 20 °C
6.2: pH 1
With
hydrogenchloride; methanol; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; sodium hydroxide; phosphorus(V) oxybromide;
palladium 10% on activated carbon;
In
ethyl acetate; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere
2.1: hydrogenchloride; water / 24 h / Reflux
3.1: sulfuric acid / 48 h / Reflux
3.2: 20 °C
4.1: sodium hydroxide; methanol / 0.02 h / 20 °C
4.2: pH 1
With
hydrogenchloride; methanol; sulfuric acid; water; hydrogen; sodium hydroxide;
palladium 10% on activated carbon;
In
ethyl acetate;
