3-Amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 3-Amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester
• CAS No.: 866775-17-9
• Molecular Formula: C8H7F3N2O2
• Molecular Weight: 220.15
• Mol file: 866775-17-9.mol

Synonyms:3-Amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 3-amino-5-(trifluoromethyl)-, methyl ester

Chemical Property of 3-Amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

Chemical Property:

• PSA: 65.21000
• LogP: 2.05040

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-amino-5-(trifluoromethyl)picolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

There total 9 articles about 3-Amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile (866775-16-8) → 3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (866775-17-9)

Guidance literature:

3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile; With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 18h;

With hydrogenchloride; water; for 24h; Reflux;

methanol; With sulfuric acid; for 84h; Reflux;

Reference yield:

methanol (67-56-1) + 3-amino-5-(trifluoromethyl)picolinic acid hydrochloride → 3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (866775-17-9)

Guidance literature:

methanol; 3-amino-5-(trifluoromethyl)picolinic acid hydrochloride; With sulfuric acid; for 48h; Reflux;

With sodium hydrogencarbonate; In methanol; water; at 20 ℃;

Reference yield:

3-nitro-5-trifluoromethylpyridin-2-ol (33252-64-1) → 3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (866775-17-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux

2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere

4.1: hydrogenchloride; water / 24 h / Reflux

5.1: sulfuric acid / 48 h / Reflux

5.2: 20 °C

With hydrogenchloride; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; phosphorus(V) oxybromide; palladium 10% on activated carbon; In ethyl acetate; toluene; acetonitrile;

upstream raw materials:

3-nitro-5-trifluoromethylpyridin-2-ol

3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile

methanol

3-amino-6-(2,6-difluorophenyl)-5-trifluoromethyl-2-pyridinecarboxylicacid

Downstream raw materials:

3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

3-amino-6-(2,4-dichlorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid

3-amino-5-trifluoromethylpyridine-2-carboxylic acid

3-amino-6-(4-fluorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid

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