Mal-amido-PEG12-acid

Base Information

• Chemical Name: Mal-amido-PEG12-acid
• CAS No.: 871133-36-7
• Molecular Formula: C₁₈H₂₈N₂O₉
• Molecular Weight: 416.428
• Mol file: 871133-36-7.mol

Synonyms:Mal-amido-PEG12-acid;Mal-N-amido-PEG24-acid

Chemical Property of Mal-amido-PEG12-acid

Chemical Property:

• PSA: 122.24000
• LogP: -0.74560

Purity/Quality:

98%Min ^*data from raw suppliers

Maleimide-NH-PEG12-CH2CH2COOH min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Mal (maleimide)-amido-PEG12-acid is a kind of sulfhydryl group reactive-polyethylene glycol derivative. It is useful in the peptide synthesis including selectively modifying protein, peptide or any other biomolecules.

Technology Process of Mal-amido-PEG12-acid

There total 17 articles about Mal-amido-PEG12-acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl 3-(2-{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy}ethoxy)propanoate → 3-(2-{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy}ethoxy)propanoic acid (756525-98-1,871133-36-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 10 - 20 ℃; for 1h;

DOI:10.1055/s-0033-1340980

Reference yield: 79.0%

3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl chloride (121215-45-0) + amino-PEG(2u)-acid (791028-27-8) → 3-(2-{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy}ethoxy)propanoic acid (756525-98-1,871133-36-7)

Guidance literature:

amino-PEG(2u)-acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 25 ℃; Large scale;

3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl chloride; In dichloromethane; at 20 ℃; Large scale;

Reference yield: 48.0%

3-maleimidopropionic acid N-hydroxysuccinimide ester (55750-62-4) + amino-PEG(2u)-acid (791028-27-8) → 3-(2-{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy}ethoxy)propanoic acid (756525-98-1,871133-36-7)

Guidance literature:

With sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 20 ℃; for 2h;

upstream raw materials:

2-methyl-2-propanyl 3-[2-(2-aminoethoxy)ethoxy]propanoate

3-maleimidepropionic acid

3-maleimidopropionic acid N-hydroxysuccinimide ester

2-methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate