tert-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate

Base Information

Chemical Name:tert-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate
CAS No.:133803-81-3
Molecular Formula:C11H22O5
Molecular Weight:234.293
Hs Code.:2918999090
DSSTox Substance ID:DTXSID90564500
Wikidata:Q82449208
Mol file:133803-81-3.mol

Synonyms:133803-81-3;Hydroxy-PEG2-t-butyl ester;tert-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate;TERT-BUTYL 3-[2-(2-HYDROXYETHOXY)ETHOXY]PROPANOATE;HO-PEG2-CH2CH2COOtBu;Hydroxy-PEG2-(CH2)2-Boc;MFCD20926380;OH-PEG2-TBA;OH-PEG2-CH2CH2COOtBu;Propanoic acid, 3-[2-(2-hydroxyethoxy)ethoxy]-, 1,1-dimethylethyl ester;HO-PEG2-t-butyl ester;Hydroxy-PEG3-t-butylester;LCZC844;SCHEMBL225095;LCZC1199;AMY2176;DTXSID90564500;OKOWESVURLUVMD-UHFFFAOYSA-N;C11H22O5;ZB0959;AKOS027338248;t-Butyl 9-hydroxy-4,7-dioxanonanoate;GS-5584;HY-W067061;PEG3-carboxylic Acid tert-Butyl Ester;BP-20520;SY122553;CS-0058621;P2719;H10208;A901385;tert-Butyl3-(2-(2-hydroxyethoxy)ethoxy)propanoate;tert-butyl 3-(2-(2-hydroxyethoxyl)ethoxy)propanoate;3-[2-(2-hydroxyethoxy)ethoxy]propionic acid t-butyl ester

Suppliers and Price of tert-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Hydroxy-PEG2-t-butylEster
500mg
$ 110.00

TCI Chemical
PEG3-carboxylic Acid tert-Butyl Ester
5G
$ 207.00

TCI Chemical
PEG3-carboxylic Acid tert-Butyl Ester
1G
$ 42.00

purepeg
HO-PEG2-CH2CH2COOtBu min.97%
1 g
$ 105.00

Matrix Scientific
tert-Butyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate
5g
$ 449.00

Crysdot
tert-Butyl3-(2-(2-hydroxyethoxy)ethoxy)propanoate 95%
5g
$ 223.00

ChemScene
Hydroxy-PEG2-(CH2)2-Boc ≥97.0%
25g
$ 764.00

ChemScene
Hydroxy-PEG2-(CH2)2-Boc ≥97.0%
1g
$ 63.00

ChemScene
Hydroxy-PEG2-(CH2)2-Boc ≥97.0%
10g
$ 382.00

ChemScene
Hydroxy-PEG2-(CH2)2-Boc ≥97.0%
5g
$ 215.00

Total 22 raw suppliers

Chemical Property of tert-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate

Chemical Property:

Boiling Point:321.8±22.0 °C(Predicted)
PKA:14.36±0.10(Predicted)
PSA：64.99000
Density:1.046±0.06 g/cm3(Predicted)
LogP:0.74370
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:234.14672380
Heavy Atom Count:16
Complexity:185

Purity/Quality:

98% ^*data from raw suppliers

Hydroxy-PEG2-t-butylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)CCOCCOCCO
Description Hydroxy-PEG2-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses Hydroxy-PEG2-(CH2)2-Boc is an ADC linker for the synthesis of antibody drug conjugates (ADC), Hydroxy-PEG2-(CH2)2-Boc is derived from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc can also be used as a PROTAC linker for PROTAC synthesis.

Technology Process of tert-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate

There total 3 articles about tert-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%