N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethanesulfonamide

Base Information

Chemical Name:N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethanesulfonamide
CAS No.:218601-21-9
Molecular Formula:C₂₃H₂₀ClN₅O₄S
Molecular Weight:0
Hs Code.:
Mol file:218601-21-9.mol

Synonyms:N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethanesulfonamide

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Chemical Property of N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethanesulfonamide

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Technology Process of N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethanesulfonamide

There total 6 articles about N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: potassium (phenethylsulfonyl)amide

: 150728-13-5
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

: 218601-21-9
N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethanesulfonamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm3009103

Reference yield: 82.0%

: 16993-47-8
2-(phenyl)ethanesulfonamide

: 150728-13-5
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

: 218601-21-9
N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethanesulfonamide

Guidance literature:: 2-(phenyl)ethanesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1016/S0968-0896(01)00187-0

Reference yield:

: 20730-58-9
2-(2-Methoxyphenoxy)propanedioic acid diethyl ester

: 218601-21-9
N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 57 percent / NaOEt / ethanol / 2.75 h / Heating

2.1: 75 percent / phosphorus oxychloride; 2,4,6-trimethylpyrimidine / 17.5 h / 90 °C

3.1: NaH / dimethylformamide / 0.17 h / 20 °C

3.2: 82 percent / dimethylformamide / 4 h / 20 °C

With 2,4,6-trimethylpyrimidine; sodium ethanolate; sodium hydride; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00187-0