4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine

Base Information

• Chemical Name: 4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine
• CAS No.: 329923-15-1
• Molecular Formula: C15H12 N4 O4
• Molecular Weight: 312.285
• Mol file: 329923-15-1.mol

Synonyms:[2,2'-Bipyrimidin]-4(1H)-one,6-hydroxy-5-(2-methoxyphenoxy)- (9CI); 4,6-Dihydroxy-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)pyrimidine

Chemical Property of 4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine

Chemical Property:

• Melting Point: 133-135°C
• Boiling Point: 557.678oC at 760 mmHg
• Flash Point: 291.074oC
• PSA: 110.48000
• Density: 1.426g/cm3
• LogP: 2.14570
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

4,6-Dihydroxy-5-(o-methoxyphenoxy)-2,2’-bipyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,6-Dihydroxy-5-(o-methoxyphenoxy)-2,2’-bipyrimidine (cas# 329923-15-1) is a compound useful in organic synthesis.

Technology Process of 4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine

There total 5 articles about 4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(2-Methoxyphenoxy)propanedioic acid diethyl ester (20730-58-9) + pyrimidine-2-carboxamidine hydrochloride → 4,6-dihydroxy-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidine (329923-15-1)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 94.02%

2-amidinopyrimidine acetate (312613-82-4) + 2-(2-Methoxyphenoxy)propanedioic acid diethyl ester (20730-58-9) → 4,6-dihydroxy-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidine (329923-15-1)

Guidance literature:

With sodium methylate; In methanol; at 65 ℃; for 3h; Product distribution / selectivity;

Reference yield: 57.0%

2-(2-Methoxyphenoxy)propanedioic acid diethyl ester (20730-58-9) + 2-pyrimidinecarboximidamide benzenesulphonate (16879-48-4) → 4,6-dihydroxy-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidine (329923-15-1)

Guidance literature:

With sodium ethanolate; In ethanol; for 2.75h; Heating;

DOI:10.1016/S0968-0896(01)00187-0

upstream raw materials:

2-(2-Methoxyphenoxy)propanedioic acid diethyl ester

2-pyrimidinecarboximidamide benzenesulphonate

(2-methoxyphenoxy)-malonic acid dimethyl ester

2-amidinopyrimidine acetate

Downstream raw materials:

4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamide citrate

p-tert-butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

N,N'-(6,6''-(ethane-1,2-diylbis(oxy))bis(5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-6,4-diyl))bis(4-(tert-butyl)benzenesulfonamide)

bosentan monohydrate