BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO

Base Information

• Chemical Name: BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO
• CAS No.: 473416-91-0
• Molecular Formula: C7H3BrF2O
• Molecular Weight: 221.001
• Hs Code.: 2913000090
• Mol file: 473416-91-0.mol

Synonyms:BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO;5-BroMo-2,4-difluorobenzaldehyde

Chemical Property of BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO

Chemical Property:

• Boiling Point: 229.4±35.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.758±0.06 g/cm3(Predicted)
• LogP: 2.53980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

5-Bromo-2,4-difluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO

There total 4 articles about BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1,5-dibromo-2,4-difluorobenzene (28342-75-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-bromo-2,4-difluorobenzaldehyde (473416-91-0)

Guidance literature:

1,5-dibromo-2,4-difluorobenzene; With n-butyllithium; In diethyl ether; hexane; at -70 ℃; for 0.5h; Cooling with ether-dry ice;

N,N-dimethyl-formamide; In diethyl ether; hexane; at -70 - 0 ℃; for 0.5h;

Reference yield: 61.0%

→ 5-bromo-2,4-difluorobenzaldehyde (473416-91-0)

Guidance literature:

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-bromo-2,4-difluorobenzaldehyde (473416-91-0)

Guidance literature:

1,5-dibromo-2,4-difluorobenzene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

N,N-dimethyl-formamide; In diethyl ether; hexane; at -78 ℃; for 0.5h;

With acetic acid; In diethyl ether; hexane; water;

upstream raw materials:

N,N-dimethyl-formamide

1,5-dibromo-2,4-difluorobenzene

2,4-difluorobromobenzene

Downstream raw materials:

5-((tert-butyldimethylsilyl)oxy)-1-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-2-methylenepentan-1-one

(R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

(R,E)-N-(1-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)ethylidene)-2-methylpropane-2-sulfinamide

1-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)ethanone

Refernces

• 1、 -. "GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES". Page/Page column 73; 74. . Retrieved 2019/05/30.
• 2、 -. "COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION". Page/Page column 38-39. . Retrieved 2012/12/13.