L-Glutamic acid-15N

Base Information

• Chemical Name: L-Glutamic acid-15N
• CAS No.: 21160-87-2
• Molecular Formula: C5H9NO4
• Molecular Weight: 148.14
• Hs Code.: 28459000
• DSSTox Substance ID: DTXSID80449110
• Nikkaji Number: J728.850F
• Wikidata: Q82268461
• Mol file: 21160-87-2.mol

Synonyms:L-Glutamic acid-15N;21160-87-2;L-glutamic-15N acid;(2S)-2-(15N)Azanylpentanedioic acid;SCHEMBL1332144;DTXSID80449110;CS-CH-00085;WAA16087;MFCD00055786;AKOS040757305;HY-14608S2;L-Glutamic acid-15N, 98 atom % 15N;CS-0356839;L-Glutamic acid-15N,2,3,3,4,4-d5, 97 atom % D, 98 atom % 15N, 95% (CP)

Chemical Property of L-Glutamic acid-15N

Chemical Property:

• Melting Point: 205 °C (dec.)(lit.)
• PSA: 100.62000
• LogP: -0.03660
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -3.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 148.05019266
• Heavy Atom Count: 10
• Complexity: 145

Purity/Quality:

NLT 98% ^*data from raw suppliers

L-Glutamic acid-15N 98 atom % ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(=O)O)C(C(=O)O)N
• Isomeric SMILES: C(CC(=O)O)[C@@H](C(=O)O)[15NH2]
• Uses: 15N-L-Glutamic acid is a N labelled L-Glutamic acid(G596960), which is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. It is also a key molecule in cellular metabolism.

Technology Process of L-Glutamic acid-15N

There total 2 articles about L-Glutamic acid-15N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

α-ketoglutaric acid (328-50-7) → 15N-glutamic acid (21160-87-2)

Guidance literature:

With ammonium-¹⁵N hydrochloride; 1,4-dihydronicotinamide adenine dinucleotide; ethanol; adenosine 5'-diphosphate; L-glutamic dehydrogenase; at 30 ℃; for 2h; tris-acetate buffer, pH 8.5;

Reference yield:

→ 15N-glutamic acid (21160-87-2)

Guidance literature:

DOI:10.1139/v69-059

Reference yield: 94.0%

15N-glutamic acid (21160-87-2) + N-(benzyloxycarbonyl)succinimide (75315-63-8) → N-(benzylcarbonyl)-L-[15N]-glutamic acid

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 90 ℃; for 1h;

DOI:10.1002/(SICI)1099-1344(199911)42:11<1103::AID-JLCR269>3.0.CO;2-E

upstream raw materials:

α-ketoglutaric acid

Downstream raw materials:

(α-15N)-L-glutamine

Refernces

• 1、 Kragl,Godde,Wandrey,Kinzy,Cappon,Lugtenburg. "Repetitive batch as an efficient method for preparative scale enzymic synthesis of 5-azido-neuroaminic acid and 15N-L-glutamic acid". . p. 1193 - 1202. Retrieved 1993.
• 2、 Cappon, J. J.,Baart, J.,Walle, G. A. M. van der,Raap, J.,Lugtenburg, J.. "Chemo-enzymatic synthesis of specifically stable-isotope labelled L-glutamic acid and 2-oxoglutaric acid". . p. 158 - 166. Retrieved 2007/10/02.