5'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one

Base Information

• Chemical Name: 5'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one
• CAS No.: 769965-95-9
• Molecular Formula: C10H8FNO
• Molecular Weight: 177.177
• Mol file: 769965-95-9.mol

Synonyms:5'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one;5'-fluoro-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one

Chemical Property of 5'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one

Chemical Property:

• Boiling Point: 351.8±42.0 °C(Predicted)
• PKA: 12.92±0.20(Predicted)
• Flash Point: 166.548oC
• PSA: 29.10000
• Density: 1.38±0.1 g/cm3(Predicted)
• LogP: 1.94740
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

5'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one

There total 7 articles about 5'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-fluoro-1-(4-methoxy-benzyl)-siprocyclopropyloxindole (769965-94-8) → 5′-fluorospiro[cyclopropane-1,3′-indoline]-2′-one (769965-95-9)

Guidance literature:

With trifluoroacetic acid; at 60 ℃;

Reference yield: 89.0%

5-fluoroindol-2(3H)-one (56341-41-4) + diphenyl(vinyl)sulfonium trifluoromethanesulfonate → 5′-fluorospiro[cyclopropane-1,3′-indoline]-2′-one (769965-95-9)

Guidance literature:

With zinc trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 21 ℃; for 4h;

DOI:10.1039/C6RA24985J

Reference yield: 78.0%

5-fluoroindol-2(3H)-one (56341-41-4) + (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate (247129-85-7) → 5′-fluorospiro[cyclopropane-1,3′-indoline]-2′-one (769965-95-9)

Guidance literature:

5-fluoroindol-2(3H)-one; (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1016/j.tet.2018.09.042

upstream raw materials:

5-fluoro-1-(4-methoxy-benzyl)-siprocyclopropyloxindole

5-fluoro-1-(4-methoxybenzyl)-1,3-dihydro-2H-indol-2-one

5-fluoro-1H-indole-2,3-dione

5-fluoro-1-(4-methoxybenzyl)-1H-indole-2,3-dione

Downstream raw materials:

trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyctohexyl}-5-(trifluoromethyl)benzamide

5’-fluorospiro[cyclopropane-1,3’-indoline]

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