trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyctohexyl}-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyctohexyl}-5-(trifluoromethyl)benzamide
CAS No.:1319742-72-7
Molecular Formula:C₂₅H₂₃ClF₄N₂O₂
Molecular Weight:494.916
Hs Code.:

Synonyms:trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyctohexyl}-5-(trifluoromethyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyctohexyl}-5-(trifluoromethyl)benzamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyctohexyl}-5-(trifluoromethyl)benzamide

There total 6 articles about trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyctohexyl}-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 769965-95-9
5′-fluorospiro[cyclopropane-1,3′-indoline]-2′-one

: 1319743-48-0
trans-methanesulfonic acid 4-(2-chloro-5-trifluoromethyl-benzoylamino)-cyclohexyl methyl ester

: 1319742-72-7
trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyctohexyl}-5-(trifluoromethyl)benzamide

Guidance literature:: 5′-fluorospiro[cyclopropane-1,3′-indoline]-2′-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.166667h; Inert atmosphere;

trans-methanesulfonic acid 4-(2-chloro-5-trifluoromethyl-benzoylamino)-cyclohexyl methyl ester; In N,N-dimethyl-formamide; mineral oil; at 70 ℃; for 2.5h;

Reference yield:

: 56341-41-4
5-fluoroindol-2(3H)-one

: 1319742-72-7
trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyctohexyl}-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexanes / 0.33 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / Inert atmosphere

2.2: 2.5 h / 70 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium hydride; In tetrahydrofuran; hexanes; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 657-05-6
2-chloro-5-trifluoromethylbenzoyl chloride

: 1319742-72-7
trans-2-chloro-N-{-4-((5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)cyctohexyl}-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 1.83 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

2.2: 0 °C

3.1: triethylamine / tetrahydrofuran; dichloromethane / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / Inert atmosphere

4.2: 2.5 h / 70 °C

With lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;