1-Piperidinecarboxylic acid, 2-(3-chloropropyl)-2-cyano-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 2-(3-chloropropyl)-2-cyano-, 1,1-diMethylethyl ester
• CAS No.: 960294-17-1
• Molecular Formula: C₁₄H₂₃ClN₂O₂
• Molecular Weight: 286.802
• Hs Code.: 2933399090
• Mol file: 960294-17-1.mol

Synonyms:1-Piperidinecarboxylic acid, 2-(3-chloropropyl)-2-cyano-, 1,1-diMethylethyl ester

Chemical Property of 1-Piperidinecarboxylic acid, 2-(3-chloropropyl)-2-cyano-, 1,1-diMethylethyl ester

Chemical Property:

• PSA: 53.33000
• LogP: 3.62668
• Storage Temp.: 2-8°C

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

tert-Butyl2-(3-chloropropyl)-2-cyanopiperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 2-(3-chloropropyl)-2-cyano-, 1,1-diMethylethyl ester

There total 1 articles about 1-Piperidinecarboxylic acid, 2-(3-chloropropyl)-2-cyano-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-tert-butoxycarbonyl-α-cyanopyrrolidine (144688-70-0) + 1.3-chlorobromopropane (109-70-6) → tert-butyl 2-(3-chloropropyl)-2-cyanopiperidine-1-carboxylate (960294-17-1)

Guidance literature:

N-tert-butoxycarbonyl-α-cyanopyrrolidine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.75h;

1.3-chlorobromopropane; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;

DOI:10.1080/00397910701571599

Reference yield: 90.0%

tert-butyl 2-(3-chloropropyl)-2-cyanopiperidine-1-carboxylate (960294-17-1) → tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate (960294-18-2)

Guidance literature:

With ammonium hydroxide; hydrogen; nickel; In methanol; at 50 ℃; for 6h; under 1551.49 Torr;

DOI:10.1080/00397910701571599

upstream raw materials:

N-tert-butoxycarbonyl-α-cyanopyrrolidine

1.3-chlorobromopropane

Downstream raw materials:

tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate

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