1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-diMethyl-2-oxo-, 1,1-diMethylethyl ester, (3S)-

Base Information

Chemical Name:1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-diMethyl-2-oxo-, 1,1-diMethylethyl ester, (3S)-
CAS No.:1268524-67-9
Molecular Formula:C9H8N2O2S
Molecular Weight:418.944
Hs Code.:
Mol file:1268524-67-9.mol

Synonyms:1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-diMethyl-2-oxo-, 1,1-diMethylethyl ester, (3S)-;1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid;(S)-tert-butyl 2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate

Suppliers and Price of 1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-diMethyl-2-oxo-, 1,1-diMethylethyl ester, (3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

ChemScene
1H-Thieno[2,3-e]-1,4-diazepine-3-aceticacid,5-(4-chlorophenyl)-2,3-dihydro-6,7-dimethyl-2-oxo-,1,1-dimethylethylester,(3S)-
1g
$ 2500.00

ChemScene
1H-Thieno[2,3-e]-1,4-diazepine-3-aceticacid,5-(4-chlorophenyl)-2,3-dihydro-6,7-dimethyl-2-oxo-,1,1-dimethylethylester,(3S)-
500mg
$ 1500.00

Total 13 raw suppliers

Chemical Property of 1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-diMethyl-2-oxo-, 1,1-diMethylethyl ester, (3S)-

Chemical Property:

Boiling Point:546.9±50.0 °C(Predicted)
PKA:12.75±0.60(Predicted)
PSA：96.00000
Density:1.30±0.1 g/cm3(Predicted)
LogP:4.48180

Purity/Quality:

99% ^*data from raw suppliers

1H-Thieno[2,3-e]-1,4-diazepine-3-aceticacid,5-(4-chlorophenyl)-2,3-dihydro-6,7-dimethyl-2-oxo-,1,1-dimethylethylester,(3S)- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-diMethyl-2-oxo-, 1,1-diMethylethyl ester, (3S)-

There total 13 articles about 1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-diMethyl-2-oxo-, 1,1-diMethylethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1268524-66-8
(S)-tert-butyl-3-amino-4-((3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2-yl)amino)-4-oxobutanoate

: 1268524-67-9
tert-butyl (S)-2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate

Guidance literature:: With silica gel; In ethanol; at 90 ℃; for 3h;

Reference yield: 86.1%

: 1268524-65-7
(S)-tert-butyl 3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-((3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2-yl)amino)-4-oxobutanoate

: 1268524-67-9
tert-butyl (S)-2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate

Guidance literature:: (S)-tert-butyl 3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-((3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2-yl)amino)-4-oxobutanoate; With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With silica gel; In toluene; at 90 ℃; for 8h;
DOI:10.1002/ange.201915896

Reference yield: 85.0%

: 50508-66-2
(2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone

: 129288-31-9
L-aspartic acid-4-t-butyl ester-NCA

: 1268524-67-9
tert-butyl (S)-2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate

Guidance literature:: (2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone; L-aspartic acid-4-t-butyl ester-NCA; With trifluoroacetic acid; In toluene; at 60 ℃; for 0.5h; Sealed tube;

With triethylamine; at 80 ℃; for 0.5h; Sealed tube;
DOI:10.1021/acs.orglett.7b00417