Clenbuterol-D9 HCl

Base Information

• Chemical Name: Clenbuterol-D9 HCl
• CAS No.: 184006-60-8
• Molecular Formula: C12H10Cl3D9N2O
• Molecular Weight: 322.706516002
• Mol file: 184006-60-8.mol

Synonyms:Clenbuterol-D9 HCl;Clenbuterol-D9 hydrochloride solution;Clenbuterol-d9 hydrochloride solution

Chemical Property of Clenbuterol-D9 HCl

Chemical Property:

• Flash Point: 9℃
• PSA: 58.28000
• LogP: 4.77120
• Storage Temp.: ?20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Clenbuterol-d9 hydrochloride analytical standard ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25-25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Clenbuterol-D9 HCl

There total 2 articles about Clenbuterol-D9 HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-amino-α-D9-tert-butylamine-3,5-dichloroacetophenone hydrochloride → D9-clenbuterol hydrochloride (184006-60-8)

Guidance literature:

With sodium tetrahydroborate; water; sodium hydroxide; In methanol; at 5 ℃; for 3h; pH=7;

Reference yield:

1-(4-amino-3,5-dichlorophenyl)-1-ethanone (37148-48-4) → D9-clenbuterol hydrochloride (184006-60-8)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(ll) bromide / ethyl acetate; chloroform / 0.33 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / chloroform / 3 h / Reflux

3: sodium tetrahydroborate / methanol / 2 h / 20 °C / Cooling with ice; Inert atmosphere

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; In methanol; chloroform; ethyl acetate;

upstream raw materials:

1-(4-amino-3,5-dichlorophenyl)-1-ethanone

Refernces

• 1、 -. "Deuterium marked D9 Synthesis method of clenbuterol hydrochloride and synthesis method of synthetic intermediate thereof". Paragraph 0046; 0052; 0053. . Retrieved 2017/08/25.