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37148-48-4

Basic information
1. Product Name: 4-Amino-3,5-dichloroacetophenone
2. Synonyms: 1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone;5-AMINO-3,5-DICHLORO ACETOPHENONE;4''-AMINO-3'',5''-DICHLOROACETOPHENONECLENBUTEROL;1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone;4-Amino-3,5-dichloroacetophenone,98%;4′-Amino-3′,5′-dichloroacetophenone,1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone;3,5-dichloro-p-aMino acetophenone;4-AMino-3,5-dichloroacetophenone, 98% 5GR
3. CAS NO:37148-48-4
4. Molecular Formula: C₈H₇Cl₂NO
5. Molecular Weight: 204.05
6. EINECS: 253-368-1
7. Product Categories: Aromatic Acetophenones & Derivatives (substituted);(intermediate of leflunomide);Chemical Amines;Amines;Aromatics
8. Mol File: 37148-48-4.mol
Chemical Properties
1. Melting Point: 162-166 °C(lit.)
2. Boiling Point: 351.5 °C at 760 mmHg
3. Flash Point: 166.4 °C
4. Appearance: /
5. Density: 1.2748 (rough estimate)
6. Vapor Pressure: 4.1E-05mmHg at 25°C
7. Refractive Index: 1.5500 (estimate)
8. Storage Temp.: Refrigerator
9. Solubility: N/A
10. PKA: -1.72±0.10(Predicted)
11. CAS DataBase Reference: 4-Amino-3,5-dichloroacetophenone(CAS DataBase Reference)
12. NIST Chemistry Reference: 4-Amino-3,5-dichloroacetophenone(37148-48-4)
13. EPA Substance Registry System: 4-Amino-3,5-dichloroacetophenone(37148-48-4)
Safety Data
1. Hazard Codes: Xi
2. Statements: 36/37/38
3. Safety Statements: 26-36-37/39
4. WGK Germany: 3
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 37148-48-4(Hazardous Substances Data)

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Usage
SDS
Synthetic route
Upstream product
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Product	FOB Price	Min.Order	Supply Ability	Supplier
Factory 4-Amino-3,5-dichloroacetophenone cas 37148-48-4 powder Cas No: 37148-48-4	USD $ 30.0-30.0 / Gram	10 Gram	200 Metric Ton/Month	Hebei Yingong New Material Technology Co.,Ltd .	Contact Supplier
4-Amino-3,5-dichloroacetophenone Cas No: 37148-48-4	No Data	No Data	Metric Ton/Day	shanghai Longyu biotechnology Co.,Ltd	Contact Supplier
4-Amino-3,5-dichloroacetophenone Manufacturer/High quality/Best price/In stock Cas No: 37148-48-4	No Data	1 Kilogram	1 Metric Ton/Day	Zibo Dorne chemical technology co. LTD	Contact Supplier
Factory 4-Amino-3,5-dichloroacetophenone cas 37148-48-4 powder Cas No: 37148-48-4	USD $ 2.0-6.0 / Kilogram	1 Kilogram	10 Metric Ton/Month	Hebei yanxi chemical co.,LTD.	Contact Supplier
Factory Supply 4-Amino-3,5-dichloroacetophenone Cas No: 37148-48-4	No Data	1 Gram	4000 Metric Ton/Day	Ality Chemical Corporation	Contact Supplier
CAS 37148-48-4 4-Amino-3,5-dichloroacetophenone Cas No: 37148-48-4	No Data	100 Gram	40 Metric Ton/Month	Shanghai CRM New Material Technology Co., LTD	Contact Supplier
Bosang CAS 37148-48-4 4-Amino-3,5-dichloroacetophenone Cas No: 37148-48-4	USD $ 23.0-27.0 / Gram	100 Gram	15000 Metric Ton/Year	Hebei Bosang International Trade Co.,Ltd.	Contact Supplier
Best price 4-Amino-3,5-dichloroacetophenone CAS 37148-48-4 Cas No: 37148-48-4	USD $ 50.0-55.0 / Kilogram	1 Kilogram	50000 Kilogram/Month	Hebei Mojin Biotechnology Co.,Ltd	Contact Supplier
High purity 3,5-Dichloro-4-aminoacetophenone CAS NO.37148-48-4 Cas No: 37148-48-4	No Data	1 Kilogram	500 Metric Ton/Month	Shanghai PengMo Biotechnology Co.,Ltd	Contact Supplier
Research Chemical Pharmaceutical Raw Powder 4-Amino-3, 5-Dichloroacetophenone CAS 37148-48-4 Lianxu Cas No: 37148-48-4	USD $ 10.0-10.0 / Kilogram	1 Kilogram	5 Metric Ton/Day	Shanxi LX New Material Co., Ltd.	Contact Supplier

37148-48-4 Usage

Chemical Properties

white to light yellow crystal powder

Uses

4-Amino-3,5-dichloroacetophenone is a compound useful in organic synthesis.

InChI:InChI=1/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3

37148-48-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name	4-Amino-3,5-dichloroacetophenone

1.2 Other means of identification

Product number	-
Other names	1-(4-Amino-3,5-dichlorophenyl)ethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:37148-48-4 SDS

37148-48-4Synthetic route

: 108-24-7
acetic anhydride

: 608-31-1
2,6-Dichloroaniline

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 0 - 20℃;	98.9%

: 75-36-5
acetyl chloride

: 608-31-1
2,6-Dichloroaniline

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

Conditions

Conditions	Yield
With iron(III) chloride In chloroform at 0 - 20℃; for 6h;	88.6%

: 99-92-3
4-Aminoacetophenone

A: 6953-83-9
1-(4-amino-3-chlorophenyl)ethan-1-one

B: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

Conditions

Conditions	Yield
With N-chloro-succinimide In acetonitrile at 20℃; for 3.5h;	A 18% B 80%
With N-chloro-succinimide In acetonitrile at 20℃; for 4.5h;	A 45% B 20%

: 99-92-3
4-Aminoacetophenone

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

Conditions

Conditions	Yield
With chlorine; acetic acid

: 7782-50-5
chlorine

: 99-92-3
4-Aminoacetophenone

: 64-19-7
acetic acid

A: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

B: 634-93-5
2,4,6-trichloroaniline

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 120215-63-6
C8H8Cl2N2O

Conditions

Conditions	Yield
With hydroxylamine In tetrahydrofuran	100%

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 37148-47-3
1-(4-amino-3,5-dichlorophenyl)-2-bromoethan-1-one

Conditions

Conditions	Yield
With bromine at 20℃; for 3h;	95.2%
Stage #1: 1-(4-amino-3,5-dichlorophenyl)-1-ethanone With bromine In chloroform for 0.5h; Reflux; Inert atmosphere; Stage #2: With triethylamine; phosphonic acid diethyl ester In tetrahydrofuran at 0 - 20℃; for 0.166667h; Inert atmosphere;	89%
Stage #1: 1-(4-amino-3,5-dichlorophenyl)-1-ethanone With bromine In tetrahydrofuran; chloroform for 0.416667h; Reflux; Stage #2: With diethyl phosphite; triethylamine In tetrahydrofuran at 20℃; for 0.166667h;	89%

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 3,5-dichloro-4-bromoacetophenone

Conditions

Conditions	Yield
With hydrogen bromide; copper(I) bromide; sodium nitrite In water at 0 - 5℃; for 4.5h;	90%

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 75-05-8
acetonitrile

: 2,6-dichloro-4-(2,6-dimethylpyrimidin-4-yl)aniline

Conditions

Conditions	Yield
With sodium hydroxide; copper dichloride at 120℃; for 24h; Schlenk technique; Inert atmosphere;	84%
With sodium hydroxide; copper dichloride at 110℃; for 20h; Inert atmosphere;	84%

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: copper dichloride

: 35981-65-8
3’,4’,5’-Trichloroacetophenone

Conditions

Conditions	Yield
With tert.-butylnitrite In acetonitrile at 65℃; for 1h; Glovebox; Schlenk technique; Reflux;	80%

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 918451-58-8
α-methyl-4-amino-3,5-dichlorobenzylamine

Conditions

Conditions	Yield
With ammonia; hydrogen In tetrahydrofuran at 120℃; for 20h;	79%

concentrated acetic acid: concentrated acetic acid

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 6303-21-5
hypophosphorous acid

: 109346-95-4
2-(3,5-dichlorophenyl)acetaldehyde

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water	70%

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 4-amino-bromo-3,5-dichloroacetophenone

Conditions

Conditions	Yield
With bromine In chloroform at 20℃; for 1h;	67%

: 24424-99-5
di-tert-butyl dicarbonate

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: N,N-Bis(tert-butoxycarbonyl)-2,6-dichloro-4-acetylaniline

Conditions

Conditions	Yield
With dmap In tetrahydrofuran Reflux; Inert atmosphere;	56%
With dmap In tetrahydrofuran at 20℃; for 50h; Reflux;	56%

: 405-05-0
3-fluoro-4-hydroxybenzaldehyde

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: (E)-1-(4-amino-3,5-dichlorophenyl)-3-(3-fluoro-4-hydroxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 120℃;	49%

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 14401-72-0
3',5'-dichloroacetophenone

Conditions

Conditions	Yield
With pyridine; hydrogenchloride; sodium nitrite Behandeln der Reaktionsloesung mit wss. H3PO2 unterhalb 5grad;

: 75-44-5
phosgene

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-17-0
2,6-dichloro-4-acetylphenyl isocyanate

Conditions

Conditions	Yield
In toluene
In toluene
In toluene

: 75-44-5
phosgene

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 124-40-3
dimethyl amine

: 60677-46-5
3,5-Dichlor-4-N,N-dimethylcarbamoylaminoacetophenon

Conditions

Conditions	Yield
(i) toluene, (ii) /BRN= 605257/; Multistep reaction;

: 75-44-5
phosgene

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 62-53-3
aniline

: 60677-48-7
3,5-dichloro-4-phenylcarbamoylaminoacetophenone

Conditions

Conditions	Yield
(i) toluene, (ii) /BRN= 605631/; Multistep reaction;

: 75-44-5
phosgene

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 108-93-0
cyclohexanol

: 60677-50-1
3,5-dichloro-4-cyclohexyloxycarbonylaminoacetophenone

Conditions

Conditions	Yield
(i) toluene, (ii) /BRN= 906744/; Multistep reaction;

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-37-4
4-carbamoylamino-3,5-dichloroacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene 2: NH3 / toluene View Scheme

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-39-6
4-carbamoylamino-3,5-dichloro-α-bromo-methyl benzyl alcohol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: toluene 2: NH3 / toluene 3: Br2 / acetic acid 4: NaBH4 View Scheme

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-35-2
3,5-dichloro-4-methylcarbamoylaminoacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene 2: toluene View Scheme

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-86-3
3,5-dichloro-4-methoxycarbonylaminoacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene 2: toluene View Scheme

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-38-5
4-carbamoylamino-3,5-dichloro-α-bromoacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: toluene 2: NH3 / toluene 3: Br2 / acetic acid View Scheme

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-52-3
3,5-dichloro-4-ethylcarbamoylaminoacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene View Scheme

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-26-1
3,5-dichloro-4-ethoxycarbonylaminoacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene 2: toluene View Scheme

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-19-2
3,5-dichloro-4-methoxycarbonylamino-α-bromomethylbenzyl alcohol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: toluene 2: toluene 3: Br2 / acetic acid 4: NaBH4 View Scheme

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-30-7
3,5-dichloro-4-isopropoxycarbonylaminoacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene View Scheme

: 37148-48-4
1-(4-amino-3,5-dichlorophenyl)-1-ethanone

: 60677-28-3
3,5-dichloro-4-n-propoxycarbonylaminoacetophenone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene View Scheme

37148-48-4Upstream product

99-92-3 4-Aminoacetophenone

37148-48-4Downstream Products

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37148-48-4

Basic information

Chemical Properties

Safety Data

37148-48-4 Suppliers

Recommended suppliersmore

37148-48-4 Usage

Chemical Properties

Uses

37148-48-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

37148-48-4Synthetic route

37148-48-4Upstream product

37148-48-4Downstream Products

Please post your buying leads,so that our qualified suppliers will soon contact you!