MELOXICAM-D3

Base Information

• Chemical Name: MELOXICAM-D3
• CAS No.: 942047-63-4
• Molecular Formula: C₁₄H₁₃N₃O₄S₂
• Molecular Weight: 354.383
• Mol file: 942047-63-4.mol

Synonyms:4-HYDROXY-2-(METHYL-D3)-1,1-DIOXO-BENZO[E]-1,2-THIAZINE-3-CARBOXYLIC ACID (5-METHYL-2-THIAZOLYL)AMIDE;MELOXICAM-D3;4-Hydroxy-2-(methyl-d3)-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1,-Dioxide;Metacam-d3;Mobic-d3;Mobicox-d3;Movalis-d3;Movatec-d3

Chemical Property of MELOXICAM-D3

Chemical Property:

• Melting Point: 249-251°C
• PSA: 139.71000
• LogP: 3.61910
• Storage Temp.: -20°C Freezer

Purity/Quality:

NLT 98% ^*data from raw suppliers

Meloxicam-d3 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Description: Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam by GC- or LC-MS. Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID). Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation. It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg. Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.
• Uses: MELOXICAM-D3 is a preferential cyclooxygenase (COX-2) inhibitor,it is used as an anti-inflammatory.

Technology Process of MELOXICAM-D3

There total 4 articles about MELOXICAM-D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxide-d3 (942047-62-3) + 5-methyl-2-thiazol-2-amine (7305-71-7) → meloxicam-d3 (942047-63-4)

Guidance literature:

In m-xylene; for 24h; Heating;

DOI:10.1002/jlcr.1261

Reference yield:

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide (6639-62-9) → meloxicam-d3 (942047-63-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 64.2 percent / MeONa / dimethylsulfoxide / 0.07 h / 30 °C

2: 52.6 percent / aq. NaOH / ethanol / 24 h

3: 60 percent / m-xylene / 24 h / Heating

With sodium hydroxide; sodium methylate; In ethanol; dimethyl sulfoxide; m-xylene;

DOI:10.1002/jlcr.1261

Reference yield:

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-14-9) → meloxicam-d3 (942047-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 52.6 percent / aq. NaOH / ethanol / 24 h

2: 60 percent / m-xylene / 24 h / Heating

With sodium hydroxide; In ethanol; m-xylene;

DOI:10.1002/jlcr.1261

upstream raw materials:

2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxide-d3

5-methyl-2-thiazol-2-amine

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Refernces