METHYL-4-HYDROXY-2-METHYL-D3-2H-1,2-BENZOTHIAZINE-3-CARBOXYLATE 1,1-DIOXIDE

Base Information

• Chemical Name: METHYL-4-HYDROXY-2-METHYL-D3-2H-1,2-BENZOTHIAZINE-3-CARBOXYLATE 1,1-DIOXIDE
• CAS No.: 942047-62-3
• Molecular Formula: C₁₁H₁₁NO₅S
• Molecular Weight: 272.254
• Mol file: 942047-62-3.mol

Synonyms:METHYL-4-HYDROXY-2-METHYL-D3-2H-1,2-BENZOTHIAZINE-3-CARBOXYLATE 1,1-DIOXIDE;4-Hydroxy-2-(Methyl-d3)-2H-1,2-benzothiazine-3-carboxylic Acid Methyl Ester 1,1-Dioxide

Chemical Property of METHYL-4-HYDROXY-2-METHYL-D3-2H-1,2-BENZOTHIAZINE-3-CARBOXYLATE 1,1-DIOXIDE

Chemical Property:

• PSA: 92.29000
• LogP: 1.73900
• Solubility.: Chloroform

Purity/Quality:

97% ^*data from raw suppliers

Methyl-4-hydroxy-2-methyl-d3-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl-4-hydroxy-2-methyl-d3-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (cas# 942047-62-3) is a compound useful in organic synthesis.

Technology Process of METHYL-4-HYDROXY-2-METHYL-D3-2H-1,2-BENZOTHIAZINE-3-CARBOXYLATE 1,1-DIOXIDE

There total 3 articles about METHYL-4-HYDROXY-2-METHYL-D3-2H-1,2-BENZOTHIAZINE-3-CARBOXYLATE 1,1-DIOXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.6%

iodomethane-d3 (865-50-9) + methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (35511-14-9) → 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxide-d3 (942047-62-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 24h;

DOI:10.1002/jlcr.1261

Reference yield:

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide (6639-62-9) → 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxide-d3 (942047-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 64.2 percent / MeONa / dimethylsulfoxide / 0.07 h / 30 °C

2: 52.6 percent / aq. NaOH / ethanol / 24 h

With sodium hydroxide; sodium methylate; In ethanol; dimethyl sulfoxide;

DOI:10.1002/jlcr.1261

Reference yield:

saccharin (81-07-2) → 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxide-d3 (942047-62-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.17 h / 0 °C

1.2: 65 percent / 3.5 h / 20 - 80 °C

2.1: 64.2 percent / MeONa / dimethylsulfoxide / 0.07 h / 30 °C

3.1: 52.6 percent / aq. NaOH / ethanol / 24 h

With sodium hydroxide; sodium methylate; sodium hydride; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.1261

upstream raw materials:

iodomethane-d3

methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide

saccharin

Downstream raw materials:

piroxicam-d3

meloxicam-d3