2-FLUORO-4-BIPHENYLMAGNESIUM BROMIDE

Base Information

• Chemical Name: 2-FLUORO-4-BIPHENYLMAGNESIUM BROMIDE
• CAS No.: 76699-46-2
• Molecular Formula: C12H8BrFMg
• Molecular Weight: 275.403
• Hs Code.: 2931900090
• Mol file: 76699-46-2.mol

Synonyms:2-FLUORO-4-BIPHENYLMAGNESIUM BROMIDE;2-FLUORO-[1,1-BIPHENYL]-4-MAGNESIUMBROMIDE;RIEKE 3094

Chemical Property of 2-FLUORO-4-BIPHENYLMAGNESIUM BROMIDE

Chemical Property:

• PSA: 0.00000
• LogP: 4.13850

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-[1,1-biphenyl]-4-magnesiumbromide 0.5M solution in THF ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F

MSDS Files:

Useful:

Technology Process of 2-FLUORO-4-BIPHENYLMAGNESIUM BROMIDE

There total 1 articles about 2-FLUORO-4-BIPHENYLMAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-3-fluoro-4-phenylbenzene (41604-19-7) → (2-fluoro-1,1’-biphenyl-4yl)magnesium bromide (76699-46-2)

Guidance literature:

With magnesium; In diethyl ether; for 0.5h; Heating;

Reference yield: 97.0%

(S,E)‐4‐phenylbut‐3‐en‐2‐yl butyrate (326804-18-6) + (2-fluoro-1,1’-biphenyl-4yl)magnesium bromide (76699-46-2) → (R)-(+)-1-phenyl-3-((3-fluoro-4-phenyl)phenyl)-1-butene (1248350-24-4)

Guidance literature:

With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at 0 ℃; for 5h; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/jo1011653

Reference yield: 95.0%

(R)-(+)-4,4-diphenyl-3-buten-2-yl acetate (942517-48-8) + (2-fluoro-1,1’-biphenyl-4yl)magnesium bromide (76699-46-2) → (S)-(+)-1,1-diphenyl-3-(3-fluoro-4-phenylphenyl)-1-butene

Guidance literature:

With copper(l) chloride; In tetrahydrofuran; at 0 ℃; for 16h;

DOI:10.1021/ol702261t

upstream raw materials:

1-bromo-3-fluoro-4-phenylbenzene

Downstream raw materials:

1-(2-Fluoro-biphenyl-4-yl)-4-propyl-cyclohexanol

N-benzyl-4-(3-fluoro-4-phenyl)phenyl-4-piperidinol

4-(3-fluoro-4-phenyl)phenyl-4-piperidinol

2'-Fluoro-4''-propyl-[1,1';4',1'']terphenyl

Refernces