4-Methoxyphenylacetic Anhydride

Base Information

• Chemical Name: 4-Methoxyphenylacetic Anhydride
• CAS No.: 3951-10-8
• Molecular Formula: C18H18O5
• Molecular Weight: 314.338
• European Community (EC) Number: 678-613-3
• DSSTox Substance ID: DTXSID30555634
• Nikkaji Number: J208.756A
• Wikidata: Q82437035
• Mol file: 3951-10-8.mol

Synonyms:4-Methoxyphenylacetic Anhydride;3951-10-8;2-(4-Methoxyphenyl)acetic anhydride;[2-(4-methoxyphenyl)acetyl] 2-(4-methoxyphenyl)acetate;2-(4-methoxyphenyl)acetyl 2-(4-methoxyphenyl)acetate;SCHEMBL3231393;DTXSID30555634;(4-Methoxyphenyl)acetic anhydride;KYCAEIXHUXBNTQ-UHFFFAOYSA-N;4-methoxyphenyl acetic acid anhydride;4-METHOXYPHENYLACETICANHYDRIDE;MFCD29050221;CS-0452092;M0968;D91416;A918703

Chemical Property of 4-Methoxyphenylacetic Anhydride

Chemical Property:

• Melting Point: 76°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 314.11542367
• Heavy Atom Count: 23
• Complexity: 343

Purity/Quality:

97% ^*data from raw suppliers

4-Methoxyphenylacetic Anhydride ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC(=O)OC(=O)CC2=CC=C(C=C2)OC

Technology Process of 4-Methoxyphenylacetic Anhydride

There total 3 articles about 4-Methoxyphenylacetic Anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-Methoxyphenylacetic acid (104-01-8) + potassium p-methoxyphenylacetate (42766-36-9) → 2-(4-methoxyphenyl)acetic anhydride (3951-10-8)

Guidance literature:

4-Methoxyphenylacetic acid; With trichloroisocyanuric acid; triphenylphosphine; In dichloromethane; at 0 - 20 ℃;

potassium p-methoxyphenylacetate; In dichloromethane; at 20 ℃; for 1.25h;

DOI:10.1515/chempap-2015-0042

Reference yield: 90.0%

4-Methoxyphenylacetic acid (104-01-8) → 2-(4-methoxyphenyl)acetic anhydride (3951-10-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In toluene; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1002/asia.201500907

Reference yield:

sodium 2-(4-methoxyphenyl)acetate (17274-18-9) + 4-methoxyphenyl-acetic chloride (4693-91-8) → 2-(4-methoxyphenyl)acetic anhydride (3951-10-8)

Guidance literature:

In benzene;

upstream raw materials:

sodium 2-(4-methoxyphenyl)acetate

4-methoxyphenyl-acetic chloride

4-Methoxyphenylacetic acid

potassium p-methoxyphenylacetate

Downstream raw materials:

7-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one

3-(4-methoxyphenyl)-6-methyl-2H-chromen-2-one

4-methoxybenzyl phenyl sulfide

6-(4-methoxybenzylidene)-3,4,6,7-tetrahydro-1H-spiro[chromeno[3,4-b]indole-2,2'-[1,3]dioxolane]

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