(R)-3-(2-Nitro-phenylaMino)-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (R)-3-(2-Nitro-phenylaMino)-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1000370-76-2
• Molecular Formula: C15H21N3O4
• Molecular Weight: 307.34494
• Mol file: 1000370-76-2.mol

Synonyms:(R)-3-(2-Nitro-phenylaMino)-pyrrolidine-1-carboxylic acid tert-butyl ester;1-PIPERIDINECARBOXYLIC ACID, 3-[(2-NITROPHENYL)AMINO]-, 1,1-DIMETHYLETHYL ESTER, (3R);(3R)-3-[(2-Nitrophenyl)amino]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property of (R)-3-(2-Nitro-phenylaMino)-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 448.8±40.0 °C(Predicted)
• PKA: 1.07±0.20(Predicted)
• Density: 1.260±0.06 g/cm3(Predicted)

Purity/Quality:

95+% ^*data from raw suppliers

1-PIPERIDINECARBOXYLICACID,3-[(2-NITROPHENYL)AMINO]-,1,1-DIMETHYLETHYLESTER,(3R) 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(2-Nitro-phenylaMino)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 3 articles about (R)-3-(2-Nitro-phenylaMino)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) + (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester (147081-49-0) → tert-butyl (R)-3-((2-nitrophenyl)amino)pyrrolidine-1-carboxylate (1000370-76-2)

Guidance literature:

(R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

ortho-nitrofluorobenzene; In N,N-dimethyl-formamide; at 80 ℃; for 16h;

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) + (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine (147081-44-5) → C15H21N3O4 (1000370-76-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/j.bmcl.2007.09.043

Reference yield:

→ C15H21N3O4 (1000370-76-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Microwave irradiation;

upstream raw materials:

ortho-nitrofluorobenzene

(R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester

(3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine

Refernces

• 1、 -. "(HETERO) ARYL IMIDAZOLONE COMPOUND". Paragraph 0085-0086. . Retrieved 2021/08/13.