3-hydroxy-N-p-tolylpropanamide

Base Information

• Chemical Name: 3-hydroxy-N-p-tolylpropanamide
• CAS No.: 199929-31-2
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Hs Code.: 2924299090
• Mol file: 199929-31-2.mol

Synonyms:3-hydroxy-N-p-tolylpropanamide;3-Hydroxy-N-(4-methylphenyl)propanamide;p-Hydracrylotoluidide

Chemical Property of 3-hydroxy-N-p-tolylpropanamide

Chemical Property:

• PSA: 49.33000
• Density: 1.172
• LogP: 1.38890

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-hydroxy-N-p-tolylpropanamide

There total 5 articles about 3-hydroxy-N-p-tolylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

p-toluidine (106-49-0,12221-03-3) + 3-hydroxypropionic acid (503-66-2) → 3-hydroxy-N-(4-methylphenyl)propanamide (199929-31-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 14h;

DOI:10.1021/acs.orglett.8b03014

Reference yield: 23.0%

N-allyl-p-toluidine (15258-46-5) → 3-hydroxy-N-(4-methylphenyl)propanamide (199929-31-2)

Guidance literature:

With oxygen; tris(p-bromophenylammoniumyl) hexachloroantimonate; In acetonitrile; at 40 ℃; for 72h;

DOI:10.1002/adsc.201500574

Reference yield:

β-phenyl hydroxypropionate (38491-60-0) + p-toluidine (106-49-0,12221-03-3) → 3-hydroxy-N-(4-methylphenyl)propanamide (199929-31-2)

Guidance literature:

With tantalum pentaethoxide; In toluene; at 23 ℃; for 24h; Reagent/catalyst; chemoselective reaction;

upstream raw materials:

β-Propiolactone

p-toluidine

N-allyl-p-toluidine

3-hydroxypropionic acid

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