Ro 13-6304

Base Information

• Chemical Name: Ro 13-6304
• CAS No.: 75078-89-6
• Molecular Formula: C₂₁H₂₂O₂
• Molecular Weight: 306.404
• Mol file: 75078-89-6.mol

Synonyms:

Chemical Property of Ro 13-6304

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ro 13-6304

There total 4 articles about Ro 13-6304 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-indan-5-yl-ethanone (4228-10-8) → p-<(E)-2-(5-indanyl)-propenyl>-benzoic acid ethylester (75078-89-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium borohydride / methanol / 1.5 h / 0 °C

2: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C

3: diethyl ether; xylene / 48 h / 100 °C

4: 1.) n-butyllithium / 1.) ether, 4 h, room temp.; 2.) ether, 0 deg C

With sodium tetrahydroborate; n-butyllithium; phosphorus tribromide; pyridine; In methanol; diethyl ether; hexane; xylene;

Reference yield:

α-methyl-5-indane methanol (4228-12-0) → p-<(E)-2-(5-indanyl)-propenyl>-benzoic acid ethylester (75078-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C

2: diethyl ether; xylene / 48 h / 100 °C

3: 1.) n-butyllithium / 1.) ether, 4 h, room temp.; 2.) ether, 0 deg C

With n-butyllithium; phosphorus tribromide; pyridine; In diethyl ether; hexane; xylene;

Reference yield:

5-(1-bromoethyl)-indane (75078-93-2) → p-<(E)-2-(5-indanyl)-propenyl>-benzoic acid ethylester (75078-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; xylene / 48 h / 100 °C

2: 1.) n-butyllithium / 1.) ether, 4 h, room temp.; 2.) ether, 0 deg C

With n-butyllithium; In diethyl ether; xylene;

upstream raw materials:

p-ethoxycarbonylbenzaldehyde

<1-(5-indanyl)ethyl>-triphenylphophonium bromide

1-indan-5-yl-ethanone

α-methyl-5-indane methanol