4228-10-8

Basic information

• Product Name: 5-ACETYLINDANE
• Synonyms: 5-Acetylindan;Ketone, 5-indanyl methyl;5-ACETYLINDANE;1-(2,3-DIHYDRO-1H-INDEN-5-YL)-1-ETHANONE;1-(2,3-DIHYDRO-1H-INDEN-5-YL)ETHAN-1-ONE;BUTTPARK 95\04-40;5-Acetylindane,97%;Acetylindane
• CAS NO: 4228-10-8
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.21
• Mol File: 4228-10-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 80 °C
• Flash Point: 85-87°C/0.05mm
• Appearance: /
• Density: 1.067 g/cm³
• Vapor Pressure: 0.00196mmHg at 25°C
• Refractive Index: 1.5600-1.5640
• CAS DataBase Reference: 5-ACETYLINDANE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ACETYLINDANE(4228-10-8)
• EPA Substance Registry System: 5-ACETYLINDANE(4228-10-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 4228-10-8(Hazardous Substances Data)

Usage

General Description

5-Acetylindane, also known as 5AI, is a novel psychoactive substance that belongs to the indane class of chemicals. It is a synthetic compound derived from the indane core structure, which is a bicyclic organic compound. 5-Acetylindane is a psychoactive stimulant and is known for its stimulating, euphoric, and entactogenic effects. It is a potent dopamine and norepinephrine reuptake inhibitor, leading to increased levels of these neurotransmitters in the brain. The chemical is known to produce mood enhancement, increased energy, and heightened focus, making it popular among users seeking recreational highs or cognitive enhancement. However, 5-Acetylindane is not approved for human consumption and is illegal in many jurisdictions due to its potential for abuse and harmful health effects with excessive use.

InChI:InChI=1/C11H12O/c1-8(12)10-6-5-9-3-2-4-11(9)7-10/h5-7H,2-4H2,1H3

Upstream product

• 496-11-7 INDANE 
• 75-36-5 acetyl chloride 
• 75-07-0 acetaldehyde 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 69849-04-3 2-(1-ethoxyethoxy)-2-lithiopropanenitrile 
• 225642-90-0 1-(2,3,5,6-tetrahydro-1H-5-indenyl)1-ethanone 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 65898-38-6 indan-5-carboxylic acid 
• 1523493-86-8 C₂₅H₂₄ClNO₄S 
• 132464-86-9 5-ethynyl-2,3-dihydro-1H-indene 
• 18775-43-4 (5-indanyl)acetonitrile 
• 1415470-61-9 (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4-methoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 1415470-65-3 (2S,3R,4R,5S,6R)-2-(7-chloro-6-(4-methoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 

Relevant articles and documents

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As a new polyphenylenepolymethylenepolyisocyanate deriv. SGLT2 inhibitor

A compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney is disclosed. A pharmaceutical composition including the compound as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes is disclosed. A method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound is provided.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.