2-Chlorophenothiazine

Base Information Edit

Chemical Name:2-Chlorophenothiazine
CAS No.:92-39-7
Molecular Formula:C12H8ClNS
Molecular Weight:233.721
Hs Code.:2934300000
European Community (EC) Number:202-152-5
NSC Number:170953,67188,17469
UNII:95H3AO2301
DSSTox Substance ID:DTXSID3057854
Nikkaji Number:J50.183B
Wikidata:Q27271788
Pharos Ligand ID:16BGPGKZRPPX
ChEMBL ID:CHEMBL1411769
Mol file:92-39-7.mol

Synonyms:2-Chlorophenothiazine;2-Chloro-10H-phenothiazine;92-39-7;10H-Phenothiazine, 2-chloro-;PHENOTHIAZINE, 2-CHLORO-;2-Chloro Phenothiazine;2-Chlorothiodiphenylamine;NSC 17469;2-chloro-phenothiazine;EINECS 202-152-5;NSC 170953;Chlorpromazine EP Impurity E;DTXSID3057854;UNII-95H3AO2301;NSC17469;NSC-17469;NSC-67188;95H3AO2301;NSC-170953;SR-01000596948-2;NSC 67188;WLN: T C666 BM ISJ EG;2-chlorphenothiazin;MFCD00005016;2-chloropheno-thiazine;cid_7088;Oprea1_205445;2-Chlorophenothiazine, 95%;2-Chlorophenothiazine, 97%;2-CL-PH;BIDD:GT0829;SCHEMBL236458;2-chloranyl-10H-phenothiazine;CHEMBL1411769;DTXCID4031643;BDBM67467;AMY23215;NSC67188;Tox21_113822;NSC170953;STK246335;AKOS001389001;CS-T-12208;CS-W020601;CAS-92-39-7;NCGC00253702-01;AS-16089;LS-105338;FT-0611988;FT-0656611;EN300-20724;2-(Hydroxymethyl)-5-methylpyrimidine-4,6-diol;C-5250;SR-01000596948;SR-01000596948-1;Q27271788;PROCHLORPERAZINE MALEATE IMPURITY D [EP IMPURITY];Z104480234;CHLORPROMAZINE HYDROCHLORIDE IMPURITY E [EP IMPURITY];Chlorpromazine impurity E, European Pharmacopoeia (EP) Reference Standard

Suppliers and Price of 2-Chlorophenothiazine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-ChloroPhenothiazine
2.5g
$ 55.00

TRC
2-ChloroPhenothiazine
500g
$ 380.00

TRC
2-ChloroPhenothiazine
250g
$ 215.00

TCI Chemical
2-Chlorophenothiazine >98.0%(GC)
500g
$ 282.00

TCI Chemical
2-Chlorophenothiazine >98.0%(GC)
25g
$ 29.00

Sigma-Aldrich
2-Chlorophenothiazine 97%
25g
$ 56.10

Sigma-Aldrich
2-Chlorophenothiazine 95%
25g
$ 56.10

Sigma-Aldrich
Chlorpromazine impurity E European Pharmacopoeia (EP) Reference Standard
y0000508
$ 190.00

Sigma-Aldrich
2-Chlorophenothiazine 95%
100g
$ 107.00

Matrix Scientific
2-Chloro-10H-phenothiazine
100g
$ 78.00

Total 148 raw suppliers

Chemical Property of 2-Chlorophenothiazine Edit

Chemical Property:

Appearance/Colour:greyish to slightly green or brownish powder
Vapor Pressure:1.81E-06mmHg at 25°C
Melting Point:197-202 °C
Refractive Index:1.68
Boiling Point:395.7 °C at 760 mmHg
PKA:-2.28±0.20(Predicted)
Flash Point:193.1 °C
PSA：37.33000
Density:1.346 g/cm³
LogP:4.68620
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated)
XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:233.0065981
Heavy Atom Count:15
Complexity:236

Purity/Quality:

99% ^*data from raw suppliers

2-ChloroPhenothiazine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC=C2C(=C1)NC3=C(S2)C=CC(=C3)Cl
Uses Metabolite of Chloropromazine 2-Chlorophenothiazine may be used as starting reagent for the synthesis of N-(10H-phenothiazin-1-yl) benzene sulphonamide.

Technology Process of 2-Chlorophenothiazine

There total 45 articles about 2-Chlorophenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 6320-02-1
o-bromothiophenol

: 6828-35-9
5-chloro-2-iodoaniline

: 92-39-7
2-chlorophenothiazine

Guidance literature:: o-bromothiophenol; 5-chloro-2-iodoaniline; With ferric citrate; In N,N-dimethyl-formamide; at 110 ℃; Green chemistry;

With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; regioselective reaction; Green chemistry;
DOI:10.2174/1570178615666180806114523

Reference yield: 92.0%

: 1009-07-0
N-(5-chloro-2-mercaptophenyl)acetamide

: 583-53-9
2,3-dibromobenzene

: 92-39-7
2-chlorophenothiazine

Guidance literature:: With ferrous(II) sulfate heptahydrate; potassium tert-butylate; 1,9-phenanthroline; In N,N-dimethyl-formamide; at 135 ℃; for 24h; Green chemistry;
DOI:10.1021/acs.joc.5b00568