BenzenaMine, 5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

Base Information

• Chemical Name: BenzenaMine, 5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
• CAS No.: 1269232-96-3
• Molecular Formula: C12H16BClFNO2
• Molecular Weight: 271.527
• Mol file: 1269232-96-3.mol

Synonyms:BenzenaMine, 5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline

Chemical Property of BenzenaMine, 5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

Chemical Property:

• Boiling Point: 379.0±42.0 °C(Predicted)
• PKA: 2.14±0.11(Predicted)
• PSA: 44.48000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 2.94170

Purity/Quality:

99%, ^*data from raw suppliers

5-Chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BenzenaMine, 5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

There total 5 articles about BenzenaMine, 5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C12H14BClFNO4 → 5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1269232-96-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 - 25 ℃; for 10h;

Reference yield: 76.0%

3-bromo-5-chloro-2-fluoroaniline (1269232-95-2) + bis(pinacol)diborane (73183-34-3) → 5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1269232-96-3)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

2-fluoro-5-chloronitrobenzene (345-18-6) → 5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1269232-96-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium bromate; potassium sulfate; sulfuric acid / water / 90 - 95 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 5 h / 80 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 20 - 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium bromate; potassium sulfate; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium acetate; In 1,4-dioxane; methanol; water;

upstream raw materials:

2-fluoro-5-chloronitrobenzene

3-bromo-5-chloro-2-fluoroaniline

bis(pinacol)diborane

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