Ethyl 7-bromo-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxylate

Base Information

• Chemical Name: Ethyl 7-bromo-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxylate
• CAS No.: 16867-56-4
• Molecular Formula: C₁₁H₉BrN₂O₃
• Molecular Weight: 297.108
• Hs Code.: 2933990090
• Mol file: 16867-56-4.mol

Synonyms:Ethyl 7-bromo-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxylate;Ethyl 7-broMo-4-oxo-4H-pyrido[1,2-a]pyriMidine-3-carboxylate;7-Bromo-4H-pyrido[1,2-a]pyrimidine-4-oxo-3-carboxylic acid ethyl ester

Chemical Property of Ethyl 7-bromo-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxylate

Chemical Property:

• Boiling Point: 359.1±52.0 °C(Predicted)
• PKA: 0.06±0.50(Predicted)
• PSA: 60.67000
• Density: 1 +-.0.1 g/cm3(Predicted)
• LogP: 1.63370
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl7-bromo-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 7-bromo-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxylate

There total 6 articles about Ethyl 7-bromo-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

diethyl 2-[[(5-bromo-2-pyridyl)amino]methylene]propanedioate (16867-58-6) → 7-bromo-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate (16867-56-4)

Guidance literature:

With phosphorus(V) oxybromide; at 80 ℃; for 4h;

Reference yield: 70.0%

C11H11BrN2O4 → 7-bromo-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate (16867-56-4)

Guidance literature:

With trichlorophosphate; at 150 ℃; for 3h; Sealed tube;

DOI:10.1016/j.molstruc.2020.129040

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) → 7-bromo-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate (16867-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5 h / 110 °C

2: PPA / 0.5 h / 130 °C

With PPA;

upstream raw materials:

5-bromo-2-pyridylamine

diethyl methoxymethylenemalonate

diethyl 2-[[(5-bromo-2-pyridyl)amino]methylene]propanedioate

diethyl 2-ethoxymethylenemalonate

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