4'-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BIPHENYL-2-OL

Base Information

• Chemical Name: 4'-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BIPHENYL-2-OL
• CAS No.: 1219741-54-4
• Molecular Formula: C18H21BO3
• Molecular Weight: 296.174
• Hs Code.: 2934999090
• Mol file: 1219741-54-4.mol

Synonyms:4'-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BIPHENYL-2-OL;4'-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-2-ol

Chemical Property of 4'-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BIPHENYL-2-OL

Chemical Property:

• PSA: 38.69000
• LogP: 3.35840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4''-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1''-biphenyl]-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BIPHENYL-2-OL

There total 5 articles about 4'-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BIPHENYL-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 4′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-2-ol (1219741-54-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

Reference yield: 57.0%

4′-bromo-[1,1′-biphenyl]-2-ol (21849-89-8) + bis(pinacol)diborane (73183-34-3) → 4′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-2-ol (1219741-54-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 18h;

DOI:10.1021/acs.jmedchem.6b00866

Reference yield:

1,4-bromoiodobenzene (589-87-7) + 6-methoxy-2-phenyl-3,4-dihydroisoquinolin-1(2H)-one (645388-69-8) → 2-(4-bromophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (1380397-97-6) + C22H20BrNO2 + 4′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-2-ol (1219741-54-4)

Guidance literature:

1,4-bromoiodobenzene; With n-butyllithium; In n-heptane; pentane; at 20 ℃; for 1h;

2-(3-fluorophenyl)-6-methoxy-3,4-dihydro-2H-isoquinolin-1-one; In tetrahydrofuran; n-heptane; pentane; at -78 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b01468

upstream raw materials:

4′-bromo-[1,1′-biphenyl]-2-ol

bis(pinacol)diborane

1,4-bromoiodobenzene

6-methoxy-2-phenyl-3,4-dihydroisoquinolin-1(2H)-one

Downstream raw materials:

methyl 5-[(6-fluoro-5-(2'-hydroxybiphenyl-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl)oxy]-2-methylbenzoate

tert-butyl 2-(6-chloro-5-(2'-hydroxybiphenyl-4-yl)-1H-benzo[d]imidazol-2-ylthio)acetate

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