ethyl 5-hydroxy-2-Methylnicotinate

Base Information

• Chemical Name: ethyl 5-hydroxy-2-Methylnicotinate
• CAS No.: 60390-47-8
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• Hs Code.: 2933399090
• Mol file: 60390-47-8.mol

Synonyms:ethyl 5-hydroxy-2-Methylnicotinate;5-hydroxy-2-methyl-nicotinic acid ethyl ester

Chemical Property of ethyl 5-hydroxy-2-Methylnicotinate

Chemical Property:

• PSA: 59.42000
• LogP: 1.27230
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl5-hydroxy-2-methylnicotinate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 5-hydroxy-2-Methylnicotinate

There total 5 articles about ethyl 5-hydroxy-2-Methylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C11H13NO4 (99856-20-9) → ethyl 5-hydroxy-2-methyl-pyridine-3-carboxylate (60390-47-8)

Guidance literature:

C₁₁H₁₃NO₄; With potassium carbonate; In methanol; at 20 ℃; for 12h;

With hydrogenchloride; In methanol; water; pH=8 - 9;

Reference yield: 56.0%

ethyl 5-amino-2-methylnicotinate (60390-42-3) → ethyl 5-hydroxy-2-methyl-pyridine-3-carboxylate (60390-47-8)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; for 0.5h; Reflux;

DOI:10.1002/anie.202010861

Reference yield:

2-methyl-3-ethoxycarbonyl-5-nitropyridine (51984-71-5) → ethyl 5-hydroxy-2-methyl-pyridine-3-carboxylate (60390-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 40 °C

2: sulfuric acid; sodium nitrite / water / 0.5 h / Reflux

With sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium nitrite; In methanol; water;

DOI:10.1002/anie.202010861

upstream raw materials:

ethyl 5-amino-2-methylnicotinate

ethyl 2-methyl nicotinate

3-(ethoxycarbonyl)-2-methylpyridine 1-oxide

C₁₁H₁₃NO₄

Downstream raw materials:

C₈H₈N₂O₂

Refernces

• 1、 Kadina, Anastasia,Kool, Eric T.,Orbai, Lucian,Park, Hyun Shin,Velema, Willem A.. "Trapping Transient RNA Complexes by Chemically Reversible Acylation". supporting information. p. 22017 - 22022. Retrieved 2020/10/02.
• 2、 -. "TRICYCLIC GYRASE INHIBITORS". . . Retrieved 2012/09/25.