5-AMINO-2-METHYL-NICOTINIC ACID ETHYL ESTER

Base Information

• Chemical Name: 5-AMINO-2-METHYL-NICOTINIC ACID ETHYL ESTER
• CAS No.: 60390-42-3
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.2
• Hs Code.: 2933399090
• Mol file: 60390-42-3.mol

Synonyms:5-AMINO-2-METHYL-NICOTINIC ACID ETHYL ESTER;Ethyl 5-amino-2-methyl-nicotinate

Chemical Property of 5-AMINO-2-METHYL-NICOTINIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 317.241°C at 760 mmHg
• PKA: 4.95±0.20(Predicted)
• Flash Point: 145.662°C
• PSA: 65.21000
• Density: 1.158g/cm³
• LogP: 1.73010
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-amino-2-methylnicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-2-METHYL-NICOTINIC ACID ETHYL ESTER

There total 6 articles about 5-AMINO-2-METHYL-NICOTINIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-methyl-3-ethoxycarbonyl-5-nitropyridine (51984-71-5) → ethyl 5-amino-2-methylnicotinate (60390-42-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 40 ℃; for 48h;

DOI:10.1002/anie.202010861

Reference yield:

ethyl 2-methyl-5-nitrobenzoate (124358-24-3) → ethyl 5-amino-2-methylnicotinate (60390-42-3)

Guidance literature:

ethyl 2-methyl-5-nitrobenzoate; With hydrogenchloride; tin(ll) chloride; In water; at 20 ℃; for 2h;

With sodium hydroxide; In hydrogenchloride; pH=9 - 10;

Reference yield:

ethyl 5-((tert-butoxycarbonyl)amino)-2-methylnicotinate (301666-75-1) → ethyl 5-amino-2-methylnicotinate (60390-42-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

2-methyl-3-ethoxycarbonyl-5-nitropyridine

ethyl aminocrotonate

ethyl 2-methyl-5-nitrobenzoate

ethyl 5-bromo-2-methyl-pyridine-3-carboxylate

Downstream raw materials:

ethyl 5-bromo-2-methyl-pyridine-3-carboxylate

ethyl 5-amino-6-bromo-2-methylnicotinate

C₂₀H₂₂FN₃O₃

ethyl 5-hydroxy-2-methyl-pyridine-3-carboxylate