2-Oxo-1,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 2-Oxo-1,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester
• CAS No.: 392331-78-1
• Molecular Formula: C₁₂H₂₀N₂O₃
• Molecular Weight: 240.302
• Hs Code.: 2933990090
• Mol file: 392331-78-1.mol

Synonyms:2-Oxo-1,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester;7-Boc-2-oxo-1,7-diaza-spiro[3.5]nonane;1,7-Diazaspiro[3.5]nonane-7-carboxylic acid, 2-oxo-, 1,1-diMethylethyl ester;7-Boc-2-oxo-1,7-diaza-spi...;tert-Butyl 2-oxo-1,7-diazaspiro[3.5]nonane-7-carboxylate

Chemical Property of 2-Oxo-1,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 411.9±45.0 °C(Predicted)
• PKA: 15.21±0.20(Predicted)
• PSA: 62.13000
• Density: 1.17
• LogP: 1.48980
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl2-oxo-1,7-diazaspiro[3.5]nonane-7-carboxylate 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Oxo-1,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

There total 1 articles about 2-Oxo-1,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isocyanate de chlorosulfonyle (1189-71-5) + tert-butyl 4-methylidenepiperidine-1-carboxylate (159635-49-1) → tert-butyl 2-oxo-1,7-diazaspiro[3.5]nonane-7-carboxylate (392331-78-1)

Guidance literature:

isocyanate de chlorosulfonyle; tert-butyl 4-methylidenepiperidine-1-carboxylate; In dichloromethane; at 0 - 20 ℃;

With sodium thiosulfate; potassium hydroxide; In dichloromethane; water; at 0 ℃; for 3h;

Reference yield: 53.0%

di-tert-butyl peroxide (110-05-4) + tert-butyl 2-oxo-1,7-diazaspiro[3.5]nonane-7-carboxylate (392331-78-1) → C14H24N2O3

Guidance literature:

With (1,2-dimethoxyethane)dichloronickel(II); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; tris[(2-pyridylmethyl)amine]; In 2,2,2-trifluoroethanol; at 25 ℃; for 16h; Irradiation;

DOI:10.1126/science.abh2623

Reference yield:

tert-butyl 2-oxo-1,7-diazaspiro[3.5]nonane-7-carboxylate (392331-78-1) → 1,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester (1180112-41-7)

Guidance literature:

tert-butyl 2-oxo-1,7-diazaspiro[3.5]nonane-7-carboxylate; With dimethylsulfide borane complex; In tetrahydrofuran; for 28h; Reflux;

With methanol; In tetrahydrofuran;

upstream raw materials:

isocyanate de chlorosulfonyle

tert-butyl 4-methylidenepiperidine-1-carboxylate

Downstream raw materials:

1,7-diazaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

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