Fluocinolone Acetonide-21-aldehyde

Base Information

• Chemical Name: Fluocinolone Acetonide-21-aldehyde
• CAS No.: 13242-30-3
• Molecular Formula: C24H28F2O6
• Molecular Weight: 450.48
• Mol file: 13242-30-3.mol

Synonyms:Fluocinolone Acetonide-21-aldehyde;Fluocinolone Acetonide EP Impurity D;Fluocinolone Acetonide Aldehyde

Chemical Property of Fluocinolone Acetonide-21-aldehyde

Chemical Property:

• Boiling Point: 551.0±50.0 °C(Predicted)
• PKA: 12.72±0.70(Predicted)
• PSA: 89.90000
• Density: 1.36±0.1 g/cm3(Predicted)
• LogP: 2.57340
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Fluocinolone Acetonide-21-aldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fluocinolone acetonide-21-aldehyde, is a derivative of Fluocinolone Acetonide (F455800), which is a Corticosteroid, used in dermatology to reduce skin inflammation and relieve itching.

Technology Process of Fluocinolone Acetonide-21-aldehyde

There total 3 articles about Fluocinolone Acetonide-21-aldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

fluocinolone Acetonide (67-73-2) → 2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoacetaldehyde (13242-30-3)

Guidance literature:

With copper diacetate; In methanol; at 20 ℃;

Reference yield:

6α,9α-difluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione-16,17-acetonide-21-acetate (3797-61-3) → 2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoacetaldehyde (13242-30-3)

Guidance literature:

With copper diacetate; In methanol; dichloromethane; water;

Reference yield:

→ 6α,9α-Difluor-11β,16α,17α-trihydroxy-3,20-dioxopregna-1,4-dien-21-al 16α,17α-acetonid-dihydrat (13242-30-3)

Guidance literature:

entspr. 11,16,17,21-Tetrahydroxyverb. (I), HOAc/Cu-acetat;

upstream raw materials:

fluocinolone Acetonide

6α,9α-difluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione-16,17-acetonide-21-acetate

Downstream raw materials:

21-oic acid of Fluocinolone Acetonide