Fluocinolone Acetonide-21-carboxylic Acid

Base Information

• Chemical Name: Fluocinolone Acetonide-21-carboxylic Acid
• CAS No.: 106931-78-6
• Molecular Formula: C₂₄H₂₈F₂O₇
• Molecular Weight: 466.479
• Mol file: 106931-78-6.mol

Synonyms:

Chemical Property of Fluocinolone Acetonide-21-carboxylic Acid

Chemical Property:

• Melting Point: >250oC (dec.)
• Boiling Point: 584.1±50.0 °C(Predicted)
• PKA: 2.39±0.54(Predicted)
• Density: 1.42±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

FluocinoloneAcetonide-21-carboxylicAcid(>90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fluocinolone Acetonide-21-carboxylic Acid, is a derivative of Fluocinolone Acetonide (F455800), which is a Corticosteroid, used in dermatology to reduce skin inflammation and relieve itching

Technology Process of Fluocinolone Acetonide-21-carboxylic Acid

There total 2 articles about Fluocinolone Acetonide-21-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

fluocinolone Acetonide (67-73-2) → 21-oic acid of Fluocinolone Acetonide (106931-78-6)

Guidance literature:

fluocinolone Acetonide; With copper diacetate;

With 3-chloro-benzenecarboperoxoic acid; for 18h;

DOI:10.1023/A:1018907026460

Reference yield:

2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoacetaldehyde (13242-30-3) → 21-oic acid of Fluocinolone Acetonide (106931-78-6)

Guidance literature:

With sodium chlorite; potassium dihydrogenphosphate; In tetrahydrofuran; water; tert-butyl alcohol; Yield given;

DOI:10.1016/S0040-4039(97)10809-7

upstream raw materials:

2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoacetaldehyde

fluocinolone Acetonide

Refernces

• 1、 Little, Roy J.,Bodor, Nicholas,Loftsson, Thorsteinn. "Soft drugs based on hydrocortisone: The inactive metabolite approach and its application to steroidal antiinflammatory agents". . p. 961 - 967. Retrieved 1999.