N-((4-Methoxybenzyl)oxy)-2-nitrobenzenesulfonaMide

Base Information

• Chemical Name: N-((4-Methoxybenzyl)oxy)-2-nitrobenzenesulfonaMide
• CAS No.: 1384122-86-4
• Molecular Formula: C14H14N2O6S
• Molecular Weight: 338.33576
• Hs Code.: 2935009090
• Mol file: 1384122-86-4.mol

Synonyms:N-((4-Methoxybenzyl)oxy)-2-nitrobenzenesulfonaMide

Chemical Property of N-((4-Methoxybenzyl)oxy)-2-nitrobenzenesulfonaMide

Chemical Property:

• Boiling Point: 514.5±60.0 °C(Predicted)
• PKA: 4.79±0.40(Predicted)
• PSA: 118.83000
• Density: 1.392±0.06 g/cm3(Predicted)
• LogP: 4.00840
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

n-((4-methoxybenzyl)oxy)-2-nitrobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-((4-Methoxybenzyl)oxy)-2-nitrobenzenesulfonaMide

There total 3 articles about N-((4-Methoxybenzyl)oxy)-2-nitrobenzenesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

O-(4-methoxybenzyl)hydroxylamine (21038-22-2) + 2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-(4-methoxybenzyloxy)-2-nitrobenzenesulfonamide (1384122-86-4)

Guidance literature:

With pyridine; In tetrahydrofuran; at 23 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo300872y

Reference yield:

N-(4-methoxybenzyloxy)phthalimide (2014-61-1) → N-(4-methoxybenzyloxy)-2-nitrobenzenesulfonamide (1384122-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / tetrahydrofuran / 1 h / 23 °C / Inert atmosphere

2: pyridine / tetrahydrofuran / 2 h / 23 °C / Inert atmosphere

With pyridine; hydrazine hydrate; In tetrahydrofuran;

DOI:10.1021/jo300872y

Reference yield:

4-Methoxybenzyl alcohol (105-13-5) → N-(4-methoxybenzyloxy)-2-nitrobenzenesulfonamide (1384122-86-4)

Guidance literature:

Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 16 h / 0 - 23 °C / Inert atmosphere

2: hydrazine hydrate / tetrahydrofuran / 1 h / 23 °C / Inert atmosphere

3: pyridine / tetrahydrofuran / 2 h / 23 °C / Inert atmosphere

With pyridine; di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo300872y

upstream raw materials:

N-(4-methoxybenzyloxy)phthalimide

4-Methoxybenzyl alcohol

O-(4-methoxybenzyl)hydroxylamine

2-Nitrobenzenesulfonyl chloride

Refernces