tert-butyl 2-(4-Methylpiperazin-1-yl)ethylcarbaMate

Base Information

• Chemical Name: tert-butyl 2-(4-Methylpiperazin-1-yl)ethylcarbaMate
• CAS No.: 1484327-92-5
• Molecular Formula: C12H25N3O2
• Molecular Weight: 243.3458
• Mol file: 1484327-92-5.mol

Synonyms:tert-butyl 2-(4-Methylpiperazin-1-yl)ethylcarbaMate

Chemical Property of tert-butyl 2-(4-Methylpiperazin-1-yl)ethylcarbaMate

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-Butyl(2-(4-Methylpiperazin-1-Yl)ethyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(4-Methylpiperazin-1-yl)ethylcarbaMate

There total 7 articles about tert-butyl 2-(4-Methylpiperazin-1-yl)ethylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methylpiperazin-1-yl)ethylamine (934-98-5) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 2-(4-methylpiperazin-1-yl)ethylcarbamate (1484327-92-5)

Guidance literature:

2-(4-methylpiperazin-1-yl)ethylamine; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

di-tert-butyl dicarbonate; In dichloromethane; at 20 ℃;

Reference yield:

1-methyl-piperazine (109-01-3) + 2-(tert-butoxycarbonylamino)ethyl methanesulfonate (96628-67-0) → tert-butyl 2-(4-methylpiperazin-1-yl)ethylcarbamate (1484327-92-5)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1128/AAC.01152-16

Reference yield:

tert-butyl (2-bromoethyl) carbamate + tert-butyl 4-methylpiperazine-1-carboxylate (53788-49-1) → tert-butyl 2-(4-methylpiperazin-1-yl)ethylcarbamate (1484327-92-5)

Guidance literature:

4-methyl-piperazine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

tert-butyl (2-bromoethyl) carbamate; With triethylamine; In acetonitrile; at 75 ℃; for 24h;

DOI:10.1021/acs.jmedchem.1c02199

upstream raw materials:

1-methyl-piperazine

2-(tert-butoxycarbonylamino)ethyl methanesulfonate

BOC-glycine

di-tert-butyl dicarbonate

Refernces

• 1、 -. "Amino pyrimidine compound and preparation method and application thereof". Paragraph 0214; 0217; 0218; 0219. . Retrieved 2018/11/22.