2-Boc-6-oxo-2-azaspiro[3.4]octane

Base Information

• Chemical Name: 2-Boc-6-oxo-2-azaspiro[3.4]octane
• CAS No.: 1363382-39-1
• Molecular Formula: C11H17NO3
• Molecular Weight: 211.25758
• Hs Code.: 2933990090
• Mol file: 1363382-39-1.mol

Synonyms:tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate;6-Oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester;6-oxo-2-azaspiro[3.3]hept...;2-Boc-6-oxo-2-azaspiro[3....;2-Boc-6-oxo-2-azaspiro[3.3]heptane;tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate;2-Azaspiro[3.4]octane-2-carboxylic acid, 6-oxo-, 1,1-dimethylethyl ester;6-Oxo-2-azaspiro[3.3]heptane-2-carboxylic acid dimethylethyl ester

Chemical Property of 2-Boc-6-oxo-2-azaspiro[3.4]octane

Chemical Property:

• Boiling Point: 331.8±35.0 °C(Predicted)
• PKA: -0.85±0.20(Predicted)
• PSA: 46.61000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 1.91440
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Boc-6-oxo-2-azaspiro[3.4]octane

There total 22 articles about 2-Boc-6-oxo-2-azaspiro[3.4]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl 7-oxo-2-azaspiro[3.4]oct-5-ene-2-carboxylate → tert-butyl 6-oxo-2-azaspiro [3.4] octane-2-carboxylate (1363382-39-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 25 ℃; for 16h;

DOI:10.1039/c9ob00306a

Reference yield:

tert-butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate → tert-butyl 6-oxo-2-azaspiro [3.4] octane-2-carboxylate (1363382-39-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 25 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c9ob00306a

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-azaspiro[3.4]octan-6-one → tert-butyl 6-oxo-2-azaspiro [3.4] octane-2-carboxylate (1363382-39-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c9ob00306a

upstream raw materials:

ethyl 3,3-ethylenedioxycyclopentanecarboxylate

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid

Downstream raw materials:

SiO₂

Refernces