Chemical Property of (2S)-2-[[(1S)-1-carboxy-3-methylbutyl]carbamoylamino]pentanedioic acid
Chemical Property:
- PSA：153.03000
- LogP:0.88470
- Storage Temp.:Store at -20°C
- Solubility.:Soluble in DMSO (up to at least mg/ml) or in Water (up to at least 25 mg/ml)
- XLogP3:0.2
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:9
- Exact Mass:304.12705098
- Heavy Atom Count:21
- Complexity:408
- Purity/Quality:
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98% *data from raw suppliers
ZJ43 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)CC(C(=O)O)NC(=O)NC(CCC(=O)O)C(=O)O
- Isomeric SMILES:CC(C)C[C@@H](C(=O)O)NC(=O)N[C@@H](CCC(=O)O)C(=O)O
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Description
ZJ43 (723331-20-2) is potent inhibitor of glutamate carboxypeptidases II (Ki = 0.8 nM) and III (Ki = 23 nM).1?It potently (IC50?= 2.4 nM) inhibited the ability of glutamate carboxypeptidase II to hydrolyze the neurotransmitter N-acetylaspartylglutamate (NAAG) resulting in an increase in synaptic levels of group II mGluRs. Peripherally administered ZJ43 increased the activation of mGluR3 by NAAG released from peripheral sensory neurites resulting in analgesia.2,3?ZJ43 has also shown efficacy in other inflammatory pain models.4,5
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Uses
ZJ 43 is a glutamate carboxypeptidase II (GCPII) and N-acetylaspartylglutamate (NAAG) inhibitor that reduces the deleterious effects of excessive extracellular glutamate.
