L-Leucine hydrochloride

Base Information

• Chemical Name: L-Leucine hydrochloride
• CAS No.: 760-84-9
• Molecular Formula: C6H13NO2^.HCl
• Molecular Weight: 167.636
• Hs Code.: 2922499990
• European Community (EC) Number: 212-083-2
• UNII: N39KV97633
• DSSTox Substance ID: DTXSID40226904
• Wikidata: Q27284503
• Mol file: 760-84-9.mol

Synonyms:L-Leucine hydrochloride;Leucine hydrochloride;760-84-9;L-Leucine HCl;UNII-N39KV97633;(2S)-2-amino-4-methylpentanoic acid hydrochloride;(2S)-2-amino-4-methylpentanoic acid;hydrochloride;EINECS 212-083-2;N39KV97633;leucine-hcl;Leucine, hydrochloride, L-;SCHEMBL247522;DTXSID40226904;L-LEUCINE MONOHYDROCHLORIDE;LEUCINE, L-, HYDROCHLORIDE;LEUCINE HYDROCHLORIDE, (-)-;LEUCINE HYDROCHLORIDE [WHO-DD];HY-W142032;CS-0201817;EN300-7645743;Q-201025;Q27284503;(S)-2-AMINO-4-METHYLPENTANOIC ACID MONOHYDROCHLORIDE

Chemical Property of L-Leucine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0309mmHg at 25°C
• Boiling Point: 225.8 °C at 760 mmHg
• Flash Point: 90.3 °C
• PSA: 63.32000
• LogP: 1.94670
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 167.0713064
• Heavy Atom Count: 10
• Complexity: 101

Purity/Quality:

99%, ^*data from raw suppliers

L-Leucine hydrochloride solution 100?mM amino acid in 0.1 M HCl, analytical standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)N.Cl
• Isomeric SMILES: CC(C)C[C@@H](C(=O)O)N.Cl

Technology Process of L-Leucine hydrochloride

There total 18 articles about L-Leucine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → L-leucine hydrochloride (760-84-9)

Guidance literature:

With sulfuric acid; sodium chloride; In neat (no solvent); at 20 ℃; for 3h; Sealed tube;

DOI:10.1039/d1ob00728a

Reference yield: 37.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → bis-L-leucine hydrochloride (760-84-9,2175-84-0,2508-63-6,24818-45-9,27493-26-1,94032-79-8)

Guidance literature:

With copper(II) choride dihydrate; In methanol; for 48h; Reflux;

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → L-leucine hydrochloride (760-84-9)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1021/jp105255b

upstream raw materials:

N-tert-butoxycarbonyl-L-leucine

L-Leucine ethyl ester

<(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl> (2R)-2-amino-4-methylvalerate

C₁₆H₃₂N₂O₄SSi

Downstream raw materials:

Fmoc-Tyr(OBu^t)-Gly-Gly-Phe-Leu-OBu^t

ZJ-43

Fmoc-Leu-OH

(S)-4-methyl-3-(4-(methyl(2-phenylpyrimidin-4-yl)amino)pyrimidin-2-ylamino)-pentanoic acid

Refernces

• 1、 -. "A chiral bis-L - leucine hydrochloride preparation and synthetic method". Paragraph 0080-0020. . Retrieved 2017/08/25.
• 2、 Zur, Arik A.,Chien, Huan-Chieh,Augustyn, Evan,Flint, Andrew,Heeren, Nathan,Finke, Karissa,Hernandez, Christopher,Hansen, Logan,Miller, Sydney,Lin, Lawrence,Giacomini, Kathleen M.,Colas, Claire,Schlessinger, Avner,Thomas, Allen A.. "LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates". supporting information. p. 5000 - 5006. Retrieved 2016/10/05.