1-Boc-3-bromo-6-fluoroindole

Base Information

Chemical Name:1-Boc-3-bromo-6-fluoroindole
CAS No.:1314406-46-6
Molecular Formula:C₁₃H₁₃BrFNO₂
Molecular Weight:314.154
Hs Code.:2933990090
Mol file:1314406-46-6.mol

Synonyms:1-Boc-3-bromo-6-fluoroindole;tert-butyl 3-bromo-6-fluoro-1H-indole-1-carboxylate;3-Bromo-6-fluoro-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester;3-bromo-6-fluoro-1H-Indole-1-Carbocylic acid 1,1-dimethylethyl ester

Suppliers and Price of 1-Boc-3-bromo-6-fluoroindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Boc-3-bromo-6-fluoroindole
100mg
$ 45.00

Crysdot
tert-Butyl3-bromo-6-fluoro-1H-indole-1-carboxylate 97%
10g
$ 468.00

Chemenu
tert-Butyl3-bromo-6-fluoro-1H-indole-1-carboxylate 95%+
10g
$ 438.00

AK Scientific
1-Boc-3-bromo-6-fluoroindole
1g
$ 177.00

Total 12 raw suppliers

Chemical Property of 1-Boc-3-bromo-6-fluoroindole

Chemical Property:

Boiling Point:371.2±45.0 °C(Predicted)
PSA：31.23000
Density:1.44±0.1 g/cm3(Predicted)
LogP:4.32610

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-3-bromo-6-fluoroindole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Boc-3-bromo-6-fluoroindole

There total 4 articles about 1-Boc-3-bromo-6-fluoroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1208459-96-4
tert-butyl 6-fluoro-1H-indole-1-carboxylate

: 1314406-46-6
3-bromo-6-fluoro-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With N-Bromosuccinimide; In dichloromethane; for 6h; under 760.014 Torr; Reflux;
DOI:10.1021/acs.jmedchem.1c00323

Reference yield: 76.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1094754-90-1
3-bromo-6-fluoro-1H-indole

: 1314406-46-6
3-bromo-6-fluoro-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 399-51-9
6-fluoro-1H-indole

: 1314406-46-6
3-bromo-6-fluoro-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 18 h / 18 °C

2: N-Bromosuccinimide / 6 h / 40 °C

With dmap; N-Bromosuccinimide; triethylamine; In dichloromethane;