(E)-2,3-Dibromoacrylic acid methyl ester

Base Information

• Chemical Name: (E)-2,3-Dibromoacrylic acid methyl ester
• CAS No.: 77809-06-4
• Molecular Formula: C4H4Br2O2
• Molecular Weight: 0
• Mol file: 77809-06-4.mol

Synonyms:(E)-2,3-Dibromoacrylic acid methyl ester;(E)-2,3-Dibromopropenoic acid methyl ester

Chemical Property of (E)-2,3-Dibromoacrylic acid methyl ester

Chemical Property:

• Boiling Point: 43 °C (0.5 mmHg)
• PSA: 26.30000
• LogP: 1.79060

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-2,3-Dibromoacrylic acid methyl ester

There total 2 articles about (E)-2,3-Dibromoacrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propynoic acid methyl ester (922-67-8) → trans-2,3-dibromopropenoic acid methyl ester (77809-06-4) + cis-2,3-dibromopropenoic acid methyl ester (26631-70-9)

Guidance literature:

With bromine; pyrographite; In dichloromethane; at 30 ℃; for 10h;

DOI:10.1246/bcsj.62.4053

Reference yield:

propynoic acid methyl ester (922-67-8) → trans-2,3-dibromopropenoic acid methyl ester (77809-06-4)

Guidance literature:

With copper(ll) bromide; In methanol; for 11h; Heating;

DOI:10.1021/jo01013a069

Reference yield: 69.0%

trans-2,3-dibromopropenoic acid methyl ester (77809-06-4) + tributylstannylethynylbenzene (3757-88-8) → (E)-methyl 2-bromo-5-phenylpent-2-en-4-ynoate (444886-85-5)

Guidance literature:

trans-2,3-dibromopropenoic acid methyl ester; tributylstannylethynylbenzene; With triphenyl-arsane; bis(benzonitrile)palladium(II) dichloride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 18h;

With potassium fluoride; In diethyl ether; for 3h;

DOI:10.1002/1099-0690(200203)2002:6<1063::AID-EJOC1063>3.0.CO;2-M

upstream raw materials:

propynoic acid methyl ester

Downstream raw materials:

cis-2,3-dibromopropenoic acid methyl ester

(E)-methyl 2-bromo-5-phenylpent-2-en-4-ynoate

Refernces