Fmoc-(2S,4S)-4-amino-1-benzoyl-pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: Fmoc-(2S,4S)-4-amino-1-benzoyl-pyrrolidine-2-carboxylic acid
• CAS No.: 204321-85-7
• Molecular Formula: C27H24N2O5
• Molecular Weight: 456.48986
• Hs Code.: 29339900
• DSSTox Substance ID: DTXSID70373258
• Wikidata: Q82161409
• Mol file: 204321-85-7.mol

Synonyms:204321-85-7;Fmoc-(2S,4S)-4-amino-1-benzoyl-pyrrolidine-2-carboxylic acid;(2S,4S)-Fmoc-4-amino-1-benzoyl-pyrrolidine-2-carboxylic acid;(2S,4S)-1-benzoyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)pyrrolidine-2-carboxylic acid;SCHEMBL3725693;DTXSID70373258;MFCD00673784;AKOS025404019;BS-21888;CS-0357165;E70975;Fmoc-(2S,4S)-4-amino-1-benzoyl-pyrrolidine-2-carboxylicacid;(2S,4S)-1-benzoyl-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyrrolidine-2-carboxylic acid;(2S,4S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-benzoylpyrrolidine-2-carboxylic acid

Chemical Property of Fmoc-(2S,4S)-4-amino-1-benzoyl-pyrrolidine-2-carboxylic acid

Chemical Property:

• PSA: 99.43000
• LogP: 4.03530
• Storage Temp.: Store at 0-5°C
• XLogP3: 4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 456.16852187
• Heavy Atom Count: 34
• Complexity: 744

Purity/Quality:

95% ^*data from raw suppliers

(2S,4S)-Fmoc-4-amino-1-benzoyl-pyrrolidine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CN(C1C(=O)O)C(=O)C2=CC=CC=C2)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
• Isomeric SMILES: C1[C@@H](CN([C@@H]1C(=O)O)C(=O)C2=CC=CC=C2)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35

Technology Process of Fmoc-(2S,4S)-4-amino-1-benzoyl-pyrrolidine-2-carboxylic acid

There total 1 articles about Fmoc-(2S,4S)-4-amino-1-benzoyl-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H20N2O3 + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → (2S,4S)-1-benzoyl-4-N-(9-fluorenylmethoxycarbonyl)aminoproline (204321-85-7)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/jm701214z

Reference yield:

(2S,4S)-1-benzoyl-4-N-(9-fluorenylmethoxycarbonyl)aminoproline (204321-85-7) + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-(tBu)Asp-OH (71989-14-5) + Fmoc-Arg(Pbf)-OH (119831-72-0,157774-30-6) → C42H60N8O11S (1073493-64-7)

Guidance literature:

Multistep reaction.;

DOI:10.1021/jm701214z

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

C₄₂H₆₀N₈O₁₁S

Refernces