N-benzyl-N-(2-phenylethyl)piperidin-4-amine

Base Information

Chemical Name:N-benzyl-N-(2-phenylethyl)piperidin-4-amine
CAS No.:879619-76-8
Molecular Formula:C₂₀H₂₆N₂
Molecular Weight:294.44
Hs Code.:
DSSTox Substance ID:DTXSID00393242
Wikidata:Q82191929
ChEMBL ID:CHEMBL5082133

Synonyms:879619-76-8;N-benzyl-N-(2-phenylethyl)piperidin-4-amine;CHEMBRDG-BB 6766468;N-benzyl-N-phenethylpiperidin-4-amine;N-Benzyl-N-(2-phenylethyl)-4-piperidinamine;CHEMBL5082133;SCHEMBL16097011;DTXSID00393242;STK232764

Suppliers and Price of N-benzyl-N-(2-phenylethyl)piperidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N-benzyl-N-(2-phenylethyl)piperidin-4-amine

Chemical Property:

Vapor Pressure:1.15E-07mmHg at 25°C
Boiling Point:431.9°C at 760 mmHg
Flash Point:156.3°C
Density:1.06g/cm³
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:294.209598838
Heavy Atom Count:22
Complexity:286

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1N(CCC2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of N-benzyl-N-(2-phenylethyl)piperidin-4-amine

There total 7 articles about N-benzyl-N-(2-phenylethyl)piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: tert-butyloxycarbonyl-4-[benzyl(phenylethyl)amino]piperidine

: 879619-76-8
4-[benzyl(phenylethyl)amino]piperidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 879619-76-8
4-[benzyl(phenylethyl)amino]piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / methanol / 0.25 h

2: sodium cyanoborohydride / methanol / 0.5 h / 20 °C

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

4: hydrogenchloride / ethyl acetate; 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; acetic acid; In 1,4-dioxane; methanol; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.1c00696

Reference yield:

: 301220-70-2
4-(N-(2-phenylethyl)amino)-1-(tert-butoxycarbonyl)piperidine

: 100-52-7
benzaldehyde

: 879619-76-8
4-[benzyl(phenylethyl)amino]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate; 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; In 1,4-dioxane; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.1c00696