tert-butyl quinoline-6-carboxylate

Base Information

• Chemical Name: tert-butyl quinoline-6-carboxylate
• CAS No.: 403605-43-6
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.27
• Mol file: 403605-43-6.mol

Synonyms:tert-butyl quinoline-6-carboxylate

Chemical Property of tert-butyl quinoline-6-carboxylate

Chemical Property:

• PSA: 39.19000
• LogP: 3.19010

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl quinoline-6-carboxylate

There total 3 articles about tert-butyl quinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl quinoline-6-carboxylate N-oxide (863492-31-3) → tert-butyl quinoline-6-carboxylate (403605-43-6)

Guidance literature:

With Eosin Y; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate; In acetonitrile; at 20 ℃; for 1h; chemoselective reaction; Inert atmosphere; Irradiation;

DOI:10.1039/d1ob00260k

Reference yield: 92.0%

Quinoline-6-carboxylic acid (10349-57-2) + tert-butyl alcohol (75-65-0) → tert-butyl quinoline-6-carboxylate (403605-43-6)

Guidance literature:

Quinoline-6-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 40 ℃; for 1h;

tert-butyl alcohol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

Reference yield:

Quinoline-6-carboxylic acid (10349-57-2) + 2-tert-butyl-1,3-diisopropylisourea (71432-55-8) → tert-butyl quinoline-6-carboxylate (403605-43-6)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 16h;

upstream raw materials:

Quinoline-6-carboxylic acid

2-tert-butyl-1,3-diisopropylisourea

tert-butyl alcohol

tert-butyl quinoline-6-carboxylate N-oxide

Refernces

• 1、 Kim, Se Hyun,An, Ju Hyeon,Lee, Jun Hee. "Highly chemoselective deoxygenation of N-heterocyclic: N -oxides under transition metal-free conditions". supporting information. p. 3735 - 3742. Retrieved 2021/05/04.
• 2、 -. "SUBSTITUTED BICYCLOCARBOXYAMIDE COMPOUNDS". Page/Page column 65. . Retrieved 2008/12/05.