ML281

Base Information

Chemical Name:ML281
CAS No.:1404437-62-2
Molecular Formula:C22H19N3O2S
Molecular Weight:389.47
Hs Code.:
Mol file:1404437-62-2.mol

Synonyms:ML281;N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide

Suppliers and Price of ML281

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ML 281
10mg
$ 475.00

TRC
ML281
10mg
$ 110.00

Tocris
ML281 ≥98%(HPLC)
10
$ 168.00

Tocris
ML281 ≥98%(HPLC)
50
$ 696.00

DC Chemicals
ML281 >98%
100 mg
$ 550.00

CSNpharm
ML281
100mg
$ 720.00

Crysdot
ML281 98+%
25mg
$ 225.00

Crysdot
ML281 98+%
250mg
$ 1046.00

Crysdot
ML281 98+%
100mg
$ 713.00

Crysdot
ML281 98+%
50mg
$ 428.00

Total 16 raw suppliers

Chemical Property of ML281

Chemical Property:

PSA：103.09000
LogP:5.10030
Storage Temp.:2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

ML 281 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses ML 281 is a potent and selective quinoxalinone-based inhibitor of STK33 effectively targeting KRAS-dependent cancers.

Technology Process of ML281

There total 2 articles about ML281 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1404437-69-9
5-isopropyl-1-(thiophene-2-carbonyl)indoline-2,3-dione

: 95-54-5
1,2-diamino-benzene

: 1404437-62-2
N-(4-isopropyl-2-(3-oxo-3,4-dihydroquinoxalin-2-yl)phenyl)thiophene-2-carboxamide

Guidance literature:: With acetic acid; In water; at 80 ℃; for 0.333333h;
DOI:10.1021/ml300246r

Reference yield:

: 5271-67-0
2-Thiophenecarbonyl chloride

: 150560-58-0
5-(1-Methylethyl)-1H-indole-2,3-dione

: 1404437-62-2
N-(4-isopropyl-2-(3-oxo-3,4-dihydroquinoxalin-2-yl)phenyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 15.17 h / 0 - 20 °C / Inert atmosphere

2: acetic acid / water / 0.33 h / 80 °C

With acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; water;
DOI:10.1021/ml300246r