[S-(R*,R*)]-[1-[(MethoxyaMino)carbonyl]-2-[(Methylsulfonyl)oxy]propyl]-carbaMic Acid 1,1-DiMethylethyl Ester

Base Information

• Chemical Name: [S-(R*,R*)]-[1-[(MethoxyaMino)carbonyl]-2-[(Methylsulfonyl)oxy]propyl]-carbaMic Acid 1,1-DiMethylethyl Ester
• CAS No.: 80575-79-7
• Molecular Formula: C₁₁H₂₂N₂O₇S
• Molecular Weight: 326.371
• Mol file: 80575-79-7.mol

Synonyms:[S-(R*,R*)]-[1-[(MethoxyaMino)carbonyl]-2-[(Methylsulfonyl)oxy]propyl]-carbaMic Acid 1,1-DiMethylethyl Ester

Chemical Property of [S-(R*,R*)]-[1-[(MethoxyaMino)carbonyl]-2-[(Methylsulfonyl)oxy]propyl]-carbaMic Acid 1,1-DiMethylethyl Ester

Chemical Property:

• PSA: 135.39000
• LogP: 2.04750
• Solubility.: Dichlormethane, Methanol

Purity/Quality:

[S-(R*,R*)]-[1-[(Methoxyamino)carbonyl]-2-[(methylsulfonyl)oxy]propyl]-carbamicAcid1,1-DimethylethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: [S-(R*,R*)]-[1-[(Methoxyamino)carbonyl]-2-[(methylsulfonyl)oxy]propyl]-carbamic Acid 1,1-Dimethylethyl Ester (cas# 80575-79-7) is a compound useful in organic synthesis.

Technology Process of [S-(R*,R*)]-[1-[(MethoxyaMino)carbonyl]-2-[(Methylsulfonyl)oxy]propyl]-carbaMic Acid 1,1-DiMethylethyl Ester

There total 3 articles about [S-(R*,R*)]-[1-[(MethoxyaMino)carbonyl]-2-[(Methylsulfonyl)oxy]propyl]-carbaMic Acid 1,1-DiMethylethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

((1S,2S)-2-Hydroxy-1-methoxycarbamoyl-propyl)-carbamic acid tert-butyl ester (80543-39-1) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid (1S,2S)-2-tert-butoxycarbonylamino-2-methoxycarbamoyl-1-methyl-ethyl ester (80575-79-7)

Guidance literature:

With pyridine; at 0 ℃; for 2h;

DOI:10.1021/jo00147a024

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → Methanesulfonic acid (1S,2S)-2-tert-butoxycarbonylamino-2-methoxycarbamoyl-1-methyl-ethyl ester (80575-79-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. KOH; 2-methyl-propan-2-ol / 5 h

2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide (WSC) / pH=4.2

3: 80 percent / pyridine / 2 h / 0 °C

With pyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In potassium hydroxide; tert-butyl alcohol;

DOI:10.1021/jo00147a024

Reference yield:

N-tert-butoxycarbonyl-L-allo-threonine (2592-18-9,23082-29-3,55674-67-4,85979-33-5,86748-77-8,23082-30-6) → Methanesulfonic acid (1S,2S)-2-tert-butoxycarbonylamino-2-methoxycarbamoyl-1-methyl-ethyl ester (80575-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide (WSC) / pH=4.2

2: 80 percent / pyridine / 2 h / 0 °C

With pyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;

DOI:10.1021/jo00147a024

upstream raw materials:

((1S,2S)-2-Hydroxy-1-methoxycarbamoyl-propyl)-carbamic acid tert-butyl ester

methanesulfonyl chloride

di-tert-butyl dicarbonate

N-tert-butoxycarbonyl-L-allo-threonine