(R)-4-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride

Base Information

• Chemical Name: (R)-4-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride
• CAS No.: 1217445-49-2
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• DSSTox Substance ID: DTXSID60704173
• Mol file: 1217445-49-2.mol

Synonyms:1217445-49-2;(R)-4-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride;(1r)-4-methoxyindanylamine hydrochloride;(1R)-4-methoxy-2,3-dihydro-1H-inden-1-amine;hydrochloride;(1r)-4-methoxyindanylamine HCl;DTXSID60704173;AKOS015923184;Y12592;(R)-4-Methoxy-2,3-dihydro-1H-inden-1-aminehydrochloride;(1R)-4-methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride;(1R)-4-Methoxy-2,3-dihydro-1H-inden-1-amine--hydrogen chloride (1/1);1391437-20-9

Chemical Property of (R)-4-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 199.0763918
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1CCC2N.Cl
• Isomeric SMILES: COC1=CC=CC2=C1CC[C@H]2N.Cl

Technology Process of (R)-4-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride

There total 3 articles about (R)-4-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-methoxylindanone (13336-31-7) → 1-amino-2,3-dihydro-4-methoxy-1H-indene (52372-96-0,1228565-96-5,1217445-49-2)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In ethanol; at 130 ℃; for 0.0333333h; Microwave irradiation;

DOI:10.1016/j.tetlet.2010.07.156

Reference yield: 54.3%

4-methoxy-1-indanone oxime (103205-24-9) → 1-amino-2,3-dihydro-4-methoxy-1H-indene (52372-96-0,1228565-96-5,1217445-49-2)

Guidance literature:

4-methoxy-1-indanone oxime; With lithium aluminium tetrahydride; In diethyl ether; at -78 ℃; Inert atmosphere; Reflux;

With water; sodium hydroxide; In diethyl ether;

Reference yield:

→ 1-amino-2,3-dihydro-4-methoxy-1H-indene (52372-96-0,1228565-96-5,1217445-49-2)

Guidance literature:

4-Methoxy-indanon-(1)-oxim, Aluminiumamalgam, Ae., Δ;

upstream raw materials:

4-methoxy-1-indanone oxime

4-methoxylindanone