(R,R,R)-Aprepitant

Base Information

Chemical Name:(R,R,R)-Aprepitant
CAS No.:1148113-53-4
Molecular Formula:C23H21F7N4O3
Molecular Weight:534.4266624
Hs Code.:2934990002
Mol file:1148113-53-4.mol

Synonyms:(R,R,R)-Aprepitant;Aprepitant Related Compound A (10 mg) (3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one);5-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one;Aprepitant Related CoMpound A;Aprepitant EP Impurity E;Aprepitant A;Aprepitant USP RC A (R,R,R-Diasteromer)

Suppliers and Price of (R,R,R)-Aprepitant

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R,R,R)-Aprepitant
25mg
$ 5095.00

American Custom Chemicals Corporation
APREPITANT RELATED COMPOUND A 95.00%
5MG
$ 504.12

AK Scientific
(R,R,R)-Aprepitant
2mg
$ 590.00

Total 15 raw suppliers

Chemical Property of (R,R,R)-Aprepitant

Chemical Property:

PKA:8.06±0.20(Predicted)
PSA：83.50000
Density:1.51±0.1 g/cm3(Predicted)
LogP:5.30230

Purity/Quality:

97% ^*data from raw suppliers

(R,R,R)-Aprepitant ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses The (R,R,R)-enantiomer of Aprepitant (A729800), the key intermediate of Aprepitant in bulk drug and formulation samples of Aprepitant. (R,R,R)-Aprepitant (Aprepitant EP Impurity E) is the (R,R,R)-enantiomer of Aprepitant (A729800), the key intermediate of Aprepitant in bulk drug and formulation samples of Aprepitant.

Technology Process of (R,R,R)-Aprepitant

There total 1 articles about (R,R,R)-Aprepitant which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 252742-72-6
3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

: 380499-06-9
(2R,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

: 1148113-53-4,221350-96-5
C₂₃H₂₁F₇N₄O₃

Guidance literature:: With potassium carbonate; In water; N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1080/00397910903221084

Reference yield:

: 1148113-53-4,221350-96-5
C₂₃H₂₁F₇N₄O₃

: 6284-40-8,97780-33-1
1-deoxy-1-(methylamino)-D-glucitol

: C₂₃H₂₂F₇N₄O₆P*2C₇H₁₇NO₅

Guidance literature:: C₂₃H₂₁F₇N₄O₃; With dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate; sodium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃;

1-deoxy-1-(methylamino)-D-glucitol; With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;
DOI:10.1016/j.cclet.2013.07.017