1,3-DICHLORO-7-NITROISOQUINOLINE

Base Information

• Chemical Name: 1,3-DICHLORO-7-NITROISOQUINOLINE
• CAS No.: 24623-46-9
• Molecular Formula: C₉H₄Cl₂N₂O₂
• Molecular Weight: 243.049
• Hs Code.: 2933499090
• Mol file: 24623-46-9.mol

Synonyms:1,3-DICHLORO-7-NITROISOQUINOLINE

Chemical Property of 1,3-DICHLORO-7-NITROISOQUINOLINE

Chemical Property:

• Melting Point: 185 °C (decomp)(Solv: acetic acid (64-19-7))
• Boiling Point: 421.6±40.0 °C(Predicted)
• PKA: -3.24±0.50(Predicted)
• PSA: 58.71000
• Density: 1.593±0.06 g/cm3(Predicted)
• LogP: 3.97300

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-DICHLORO-7-NITROISOQUINOLINE

There total 3 articles about 1,3-DICHLORO-7-NITROISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-nitro-isoquinoline-1,3-diol (103029-78-3) → 1,3-Dichlor-7-nitro-isochinolin (24623-46-9)

Guidance literature:

With trichlorophosphate;

Reference yield:

2-(carboxymethyl)-5-nitrobenzoic acid (3898-66-6) → 1,3-Dichlor-7-nitro-isochinolin (24623-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,2-dichloro-benzene; ammonia / 165 - 170 °C

2: phosphoryl chloride

With ammonia; 1,2-dichloro-benzene; trichlorophosphate;

Reference yield:

→ 1,3-Dichlor-7-nitro-isochinolin (24623-46-9)

Guidance literature:

6-Nitro-2-oximino-indanon-(1), POCl3 1.)PCl5 <0grad, 2h>, Saettigung mit HCl-Gas 2.) <60grad, 12h> 3.)PCl5 <80grad, 6h>;

upstream raw materials:

7-nitro-isoquinoline-1,3-diol

2-(carboxymethyl)-5-nitrobenzoic acid