2-Benzyloxy-5-bromobenzylbromide

Base Information

• Chemical Name: 2-Benzyloxy-5-bromobenzylbromide
• CAS No.: 177759-47-6
• Molecular Formula: C₁₄H₁₂Br₂O
• Molecular Weight: 356.057
• DSSTox Substance ID: DTXSID601236878
• Mol file: 177759-47-6.mol

Synonyms:177759-47-6;2-benzyloxy-5-bromobenzylbromide;SCHEMBL561347;2-benzyloxy-5-bromobenzyl bromide;GFUCAZKENBZQDL-UHFFFAOYSA-N;DTXSID601236878;2-bromomethyl-4-bromophenyl benzyl ether;1-Benzyloxy-4-bromo-2-bromomethyl-benzene;1-(benzyloxy)-2-bromomethyl-4-bromobenzene;FT-0728856;4-bromo-2-(bromomethyl)phenyl phenylmethyl ether;4-Bromo-2-(bromomethyl)-1-(phenylmethoxy)benzene

Chemical Property of 2-Benzyloxy-5-bromobenzylbromide

Chemical Property:

• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 355.92344
• Heavy Atom Count: 17
• Complexity: 216

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=C(C=C(C=C2)Br)CBr

Technology Process of 2-Benzyloxy-5-bromobenzylbromide

There total 7 articles about 2-Benzyloxy-5-bromobenzylbromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

[2-(Benzyloxy)-5-bromophenyl]methanol (177759-46-5) → 2-bromomethyl-4-bromophenyl benzyl ether (177759-47-6)

Guidance literature:

With phosphorus tribromide; In toluene; for 2.66667h; Inert atmosphere; Cooling with ice; Reflux;

Reference yield:

benzyl bromide (100-39-0) → 2-bromomethyl-4-bromophenyl benzyl ether (177759-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / ethanol

2: PBr₃

With sodium hydroxide; phosphorus tribromide; In ethanol;

DOI:10.1016/j.bmcl.2006.06.086

Reference yield:

5-bromo-2-hydroxybenzyl alcohol (2316-64-5) → 2-bromomethyl-4-bromophenyl benzyl ether (177759-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / ethanol

2: PBr₃

With sodium hydroxide; phosphorus tribromide; In ethanol;

DOI:10.1016/j.bmcl.2006.06.086

upstream raw materials:

[2-(Benzyloxy)-5-bromophenyl]methanol

benzyl bromide

5-bromo-2-hydroxybenzyl alcohol

5-bromosalicyclaldehyde

Downstream raw materials:

1-({5-bromo-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carboxylic acid