3-CHLORO-1-(2-METHYLPHENYL)-1-OXOPROPANE

Base Information

• Chemical Name: 3-CHLORO-1-(2-METHYLPHENYL)-1-OXOPROPANE
• CAS No.: 898785-08-5
• Molecular Formula: C10H11ClO
• Molecular Weight: 182.65
• Hs Code.: 2914700090
• Mol file: 898785-08-5.mol

Synonyms:3-CHLORO-1-(2-METHYLPHENYL)-1-OXOPROPANE

Chemical Property of 3-CHLORO-1-(2-METHYLPHENYL)-1-OXOPROPANE

Chemical Property:

• Vapor Pressure: 0.00349mmHg at 25°C
• Boiling Point: 281.8°C at 760 mmHg
• Flash Point: 143.9°C
• PSA: 17.07000
• Density: 1.106g/cm³
• LogP: 2.80660

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-1-(2-methylphenyl)-1-oxopropane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-1-(2-METHYLPHENYL)-1-OXOPROPANE

There total 1 articles about 3-CHLORO-1-(2-METHYLPHENYL)-1-OXOPROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

toluene (108-88-3,15644-74-3,16713-13-6) + 2-chloropropionyl chloride (625-36-5) → C10H11ClO (898785-08-5) + 4'-methyl-3-chloropropiophenone (22422-21-5)

Guidance literature:

With aluminum (III) chloride; In carbon disulfide; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/jo801568a

Reference yield: 48.0%

C10H11ClO (898785-08-5) + dimethyl propargylmalonate (107428-17-1) → dimethyl 2-(but-2-ynyl)-2-(3-oxo-3-o-tolylpropyl)malonate (1357173-41-1)

Guidance literature:

dimethyl propargylmalonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

C₁₀H₁₁ClO; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 5h; Inert atmosphere; Reflux;

DOI:10.1021/ja210388g

Reference yield:

C10H11ClO (898785-08-5) → (Z)-dimethyl 2-(but-2-ynyl)-2-(3-o-tolyl-3-(triisopropylsilyloxy)allyl)malonate (1357172-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere; Reflux

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 °C / Inert atmosphere

With n-butyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; hexane; mineral oil;

DOI:10.1021/ja210388g

upstream raw materials:

toluene

2-chloropropionyl chloride

Downstream raw materials:

(Z)-dimethyl 2-(but-2-ynyl)-2-(3-o-tolyl-3-(triisopropylsilyloxy)allyl)malonate

(Z)-dimethyl 3-ethylidene-4-(2-methylbenzoyl)cyclopentane-1,1-dicarboxylate

dimethyl 2-(but-2-ynyl)-2-(3-oxo-3-o-tolylpropyl)malonate

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