1,5-bis-Boc-1,5,9-triazanonane

Base Information

• Chemical Name: 1,5-bis-Boc-1,5,9-triazanonane
• CAS No.: 122248-82-2
• Molecular Formula: C16H33N3O4
• Molecular Weight: 331.456
• Hs Code.: 29225090
• Mol file: 122248-82-2.mol

Synonyms:1,5-bis-Boc-1,5,9-triazanonane;N1,N4-bis-Boc-norsperMidine;N-(3-aminopropyl)-N-[3-[[(1,1-dimethylethoxy)carbonyl]amino]propyl]Carbamic acid 1,1-dimethylethyl ester

Chemical Property of 1,5-bis-Boc-1,5,9-triazanonane

Chemical Property:

• PSA: 93.89000
• LogP: 3.57830

Purity/Quality:

98%min ^*data from raw suppliers

1,5-Bis-Boc-1,5,9-triazanonane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 1,5-Bis-Boc-1,5,9-triazanonane is a linker containing two Boc-protected amino groups and a terminal amine. The Boc groups can be deprotected under mild acidic conditions to form the free amines. The terminal amine is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Technology Process of 1,5-bis-Boc-1,5,9-triazanonane

There total 21 articles about 1,5-bis-Boc-1,5,9-triazanonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

{3-[(3-Benzyloxycarbonylamino-propyl)-tert-butoxycarbonyl-amino]-propyl}-carbamic acid tert-butyl ester (122248-81-1) → N-(3-aminopropyl)-N,N'-bis(tert-butoxycarbonyl)propane-1,3-diamine (122248-82-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.3987/COM-88-4547

Reference yield: 68.0%

(3-tert-BOCamino-propyl)-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamic acid tert-butyl ester (647033-95-2) → N-(3-aminopropyl)-N,N'-bis(tert-butoxycarbonyl)propane-1,3-diamine (122248-82-2)

Guidance literature:

With hydrazine hydrate; In methanol; for 12h; Heating;

DOI:10.1021/jm030313f

Reference yield: 57.0%

bis(3-aminopropyl)amine (56-18-8) + di-tert-butyl dicarbonate (24424-99-5) → N-(3-aminopropyl)-N,N'-bis(tert-butoxycarbonyl)propane-1,3-diamine (122248-82-2)

Guidance literature:

bis(3-aminopropyl)amine; With ethyl trifluoroacetate,; In methanol; at -78 ℃; for 0.5h;

di-tert-butyl dicarbonate; In methanol; at 0 ℃; for 4h;

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1016/j.bmc.2019.115160

upstream raw materials:

{3-[(3-Benzyloxycarbonylamino-propyl)-tert-butoxycarbonyl-amino]-propyl}-carbamic acid tert-butyl ester

N¹,N³-bis(2-cyanoethyl)-N¹,N³-bis(1,1-dimethylethoxycarbonyl)propane-1,3-diamine

(3-tert-BOCamino-propyl)-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamic acid tert-butyl ester

(3-tert-butoxycarbonylaminobutyl)-(2-cyanoethyl)carbamic acid tert-butyl ester

Downstream raw materials:

[3-(3-Benzyloxy-4-methyl-2-nitro-benzoylamino)-propyl]-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester

C₂₂H₃₆N₄O₈S

N¹,N⁴-bis(tert-butoxycarbonyl)-N⁷-(mesitylenesulfonyl)norspermidine

C₂₆H₃₈Br₃N₃O₆

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